Objective: To assess the association between fluid overload (FO) and other risk fac tors in the mortality of patients admitted to the Pediatric Intensive Care Unit (PICU).
Patients And Method: A historical cohort study was conducted. Pediatric patients older than one month and younger than 18 years who were hospitalized in the PICU for more than 48 hours during 2016 were included. Demographic and clinical data were recorded. FO was calculated as [Sum of daily (fluid in - fluid out)/weight at ICU admission] x 100. Poisson regression analysis was perfor med to determine factors associated with mortality.
Results: 171 patients were included. The median age was 31 months (RIQ 8; 84). Mortality was 8.18%. FO in the surviving population was 7% and 11.5% in the deceased patients (p < 0.05). The adjusted analysis identified FO as a major risk factor for mortality with a Relative Risk 1.32 (1.24 - 1.40); age and Glasgow Coma Scale were protective factors.
Conclusion: Fluid overload is an independent risk factor for mortality in the analyzed PICU cohort.
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http://dx.doi.org/10.32641/andespediatr.v93i4.4043 | DOI Listing |
Cureus
February 2025
Pulmonary and Critical Care Medicine, Piedmont Athens Regional Medical Center, Athens, USA.
Staphylococcal infection is as common as streptococcal infection as a cause of infection-related glomerulonephritis (IRGN). It is seen more frequently in the pediatric population and is relatively rare in adults. Glomerular disease manifests as either nephritic or nephrotic syndrome.
View Article and Find Full Text PDFFront Physiol
February 2025
German Aerospace Center (DLR), Institute of Aerospace Medicine, Cologne, Germany.
After longer duration space missions, some astronauts experience structural and functional changes in the eye and structural changes in the brain, termed Spaceflight-Associated Neuro-Ocular Syndrome (SANS). Countermeasures against SANS are required to minimize potential operation impacts and negative long-term health consequences. Headward fluid shifts, which appear to promote SANS, provide a target for countermeasures.
View Article and Find Full Text PDFNeuropathology
March 2025
Department of Pathology, Tokyo Women's Medical University, Tokyo, Japan.
Oxidative stress in sporadic amyotrophic lateral sclerosis (ALS) has been evidenced by accumulation of oxidatively modified products of nucleic acids, lipids, sugars, and proteins in the motor neuron system of brains and spinal cords obtained at autopsy from the patients. We recently demonstrated soluble iron accumulation in activated microglia of sporadic ALS spinal cords. This finding could indicate that iron-mediated Fenton reaction is most likely to be responsible for oxidative stress associated with this disease.
View Article and Find Full Text PDFPediatr Crit Care Med
March 2025
Division of Pediatric Critical Care, Riley Hospital for Children, Indianapolis, IN.
Objective: Fluid overload (FO) after pediatric cardiac surgery with cardiopulmonary bypass (CPB) is common and has been associated with poor outcomes. We aimed to describe the relationship between plasma concentrations of syndecan-1 (SD1), a biomarker of endothelial glycocalyx injury, and FO in a cohort of children undergoing cardiac surgery.
Design: Single-center prospective observational pilot study, 2022-2023.
Crit Care
March 2025
Perioperative Medicine and Intensive Care, B31, Karolinska University Hospital, Huddinge, Sweden.
Introduction: Albumin kinetics in septic shock have been extensively studied, but clinical recommendations remain weak. An increased transcapillary escape rate (TER) of albumin has been demonstrated, though TER does not account for lymphatic return. Mass balance calculations, considering lymphatic return, have been used to assess net albumin leakage (NAL) in major surgery but not in sepsis.
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