AI Article Synopsis
- Training mice for perceptual tasks using medial forebrain bundle (MFB) stimulation instead of traditional rewards improves the number of trials per session without causing deprivation.
- The protocol includes steps for MFB electrode implantation, testing its efficacy, and calibrating stimulation to ensure effective use.
- This MFB reward system enhances the training of sensory discrimination tasks in mice, contributing to a better understanding of their psychophysical abilities.
Article Abstract
Training mice to perform perceptual tasks is a vital part of integrative neuroscience. Replacing classical rewards like water with medial forebrain bundle (MFB) stimulation allows experimenters to avoid deprivation and obtain higher trial numbers per session. Here, we provide a protocol for implementing MFB-based reward in mice. We describe steps for MFB electrode implantation, efficacy testing, and stimulation calibration. After these steps, MFB reward can be used to facilitate sensory discrimination task training and enable nuanced characterization of psychophysical abilities. For complete details on the use and execution of this protocol, please refer to Verdier et al. (2022)..
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630816 | PMC |
| http://dx.doi.org/10.1016/j.xpro.2023.102669 | DOI Listing |
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