The proportion of VREfm among all isolated from blood cultures in German hospitals has increased in the period 2015-2020 from 11.9% to 22.3% with a country-wide spread of the clonal lineage ST117/CT71 . In this study, we provided useful information about the genetic diversity of invasive strains of . Moreover, our findings confirm the nosocomial spread of novel ST1299 lineages, which recently had a rapid expansion in Austria and the south-eastern part of Germany.
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| http://dx.doi.org/10.1128/spectrum.02962-23 | DOI Listing |
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High prevalence of the recently identified clonal lineage ST1299/CT3109 among vancomycin-resistant strains isolated from municipal wastewater.
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Bayerisches Landesamt für Gesundheit und Lebensmittelsicherheit, Erlangen, Germany.
Previously, we demonstrated that the majority of vancomycin-resistant (VREfm) strains from in-patients of the University Hospital Erlangen, Germany, belonged to only three clonal lineages, namely ST117/CT71 and two novel ST1299 lineages classified as CT3109 and CT1903. The goal of the current study was (i) to investigate whether VREfm is also detectable in wastewater of the city of Erlangen, (ii) to identify their molecular features, and (iii) to clarify whether VREfm could arise from the community of the city of Erlangen or can be (directly) connected to nosocomial infections in the hospital setting. From April to May 2023, a total of 244 VREfm strains from raw wastewater of the city of Erlangen were analyzed by core genome multilocus sequence typing (cgMLST).
View Article and Find Full Text PDFEmergence of novel ST1299 lineages as possible cause for the striking rise of vancomycin resistance among invasive strains of at a German university hospital.
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Mikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany.
The proportion of VREfm among all isolated from blood cultures in German hospitals has increased in the period 2015-2020 from 11.9% to 22.3% with a country-wide spread of the clonal lineage ST117/CT71 .
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