AI Article Synopsis
- - The study compares two types of radiotherapy for breast cancer patients: hypofractionated whole-breast irradiation (HF+boost) and conventionally fractionated whole-breast irradiation (CF+boost) to see which is more effective in preventing local cancer return.
- - Out of 128 patients treated with HF+boost and 127 with CF+boost, those receiving HF+boost experienced significantly lower rates of severe skin reactions (16.4% vs. 44.1%), while severe lung complications were similar in both groups.
- - Both treatment methods showed comparable long-term outcomes in terms of local control, metastases-free survival, and overall survival, with HF+boost providing a better side effect profile.
Article Abstract
Background/aim: Many breast cancer patients receive adjuvant radiotherapy. Tumor bed boost may reduce risk of local failure in high risk patients. We compared hypofractionated whole-breast irradiation (WBI) plus boost (HF+boost) and conventionally fractionated WBI plus boost (CF+boost).
Patients And Methods: One-hundred-and-twenty-eight patients receiving HF-WBI (40 Gy in 15 fractions) plus boost (group A) were matched to 127 patients receiving CF-WBI (50.4 Gy in 28 fractions) plus boost (group B), utilizing 10 characteristics.
Results: Grade ≥2 dermatitis rates were 16.4% in group A vs. 44.1% in group B (p<0.0001), and grade ≥2 pneumonitis rates were 1.6% vs. 2.4% (p=0.68). Four-year rates of local control, metastases-free survival, and overall survival were 100% vs. 99% (p=0.81), 98% vs. 100% (p=0.29), and 98% vs. 100% (p=0.17), respectively.
Conclusion: HF+boost was associated with significantly less grade ≥2 dermatitis with similar disease control and survival.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621455 | PMC |
| http://dx.doi.org/10.21873/invivo.13370 | DOI Listing |
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