Inference of directed biological networks is an important but notoriously challenging problem. We introduce , an approach to learning causal networks that leverages large-scale intervention-response data. Applied to 788 genes from the genome-wide perturb-seq dataset, helps elucidate the network architecture of blood traits.
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http://dx.doi.org/10.1101/2023.10.13.562293 | DOI Listing |
Sci Adv
January 2025
Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Genes on the X chromosome are extensively expressed in the human brain. However, little is known for the X chromosome's impact on the brain anatomy, microstructure, and functional networks. We examined 1045 complex brain imaging traits from 38,529 participants in the UK Biobank.
View Article and Find Full Text PDFPLoS One
January 2025
Robotics and Internet-of-Things Laboratory, Prince Sultan University, Riyadh, Saudi Arabia.
The performance of drones, especially for time-sensitive tasks, is critical in various applications. Fog nodes strategically placed near IoT devices serve as computational resources for drones, ensuring quick service responses for deadline-driven tasks. However, the limited battery capacity of drones poses a challenge, necessitating energy-efficient Internet of Drones (IoD) systems.
View Article and Find Full Text PDFPsychiatry Clin Neurosci
January 2025
Shanghai Artificial Intelligence Laboratory, Shanghai, China.
Large language models (LLMs) have gained significant attention for their capabilities in natural language understanding and generation. However, their widespread adoption potentially raises public mental health concerns, including issues related to inequity, stigma, dependence, medical risks, and security threats. This review aims to offer a perspective within the actor-network framework, exploring the technical architectures, linguistic dynamics, and psychological effects underlying human-LLMs interactions.
View Article and Find Full Text PDFJ Phys Chem A
January 2025
Facultad de Ingeniería, Arquitectura y Diseño, Universidad San Sebastián, Bellavista 7, Santiago 8420524, Chile.
Covalent-organic frameworks (COFs) are useful architectures for two- (2D) and three-dimensional (3D) active materials. Recently, the characterization of the nonplanar benzo[5,6][1,4]dithiino[2,3-]thianthrene-6,13-dicarbonitrile (bTEpCN), as a prototypical section of 2D COFs, enables further understanding of the properties on such extended networks. Upon adsorption on the Au(111) surface, planarization of bTEpCN is achieved.
View Article and Find Full Text PDFSports (Basel)
January 2025
Aragon Institute of Engineering Research, University of Zaragoza, 50018 Zaragoza, Spain.
This study presents a novel system for diagnosing and evaluating soccer performance using wearable inertial sensors integrated into players' insoles. Designed to meet the needs of professional podiatrists and sports practitioners, the system focuses on three key soccer-related movements: passing, shooting, and changes of direction (CoDs). The system leverages low-power IMU sensors, Bluetooth Low Energy (BLE) communication, and a cloud-based architecture to enable real-time data analysis and performance feedback.
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