AI Article Synopsis
- The study analyzed recurrence patterns of hepatocellular carcinoma (HCC) in 1204 patients who underwent liver resection over 11 years, identifying key recurrence times and risk factor influences.
- The overall recurrence hazard peaked at 7.2 months post-surgery, with significant variations based on factors such as tumor burden, alpha-fetoprotein levels, and tumor staging.
- Patients with high recurrence risk factors experienced earlier peaks in recurrence within the first year, while those with cirrhosis faced peaks within three years, highlighting the need for tailored surveillance strategies based on individual risk profiles.
Article Abstract
Predicting recurrence patterns of hepatocellular carcinoma (HCC) can be helpful in developing surveillance strategies. This study aimed to use the hazard function to investigate recurrence hazard and peak recurrence time transitions in patients with HCC undergoing liver resection (LR). We enrolled 1204 patients with HCC undergoing LR between 2007 and 2018 at our institution. Recurrence hazard, patterns, and peak rates were analyzed. The overall recurrence hazard peaked at 7.2 months (peak hazard rate [pHR]: 0.0197), but varied markedly. In subgroups analysis based on recurrence risk factors, patients with a high radiographic tumor burden score (pHR: 0.0521), alpha-fetoprotein level ≥ 400 ng/ml (pHR: 0.0427), and pT3-4 (pHR: 0.0656) showed a pronounced peak within the first year after LR. Patients with cirrhosis showed a pronounced peak within three years after LR (pHR: 0.0248), whereas those with Barcelona Clinic Liver Cancer stage B (pHR: 0.0609) and poor tumor differentiation (pHR: 0.0451) showed multiple peaks during the 5-year follow-up period. In contrast, patients without these recurrence risk factors had a relatively flat hazard function curve. HCC recurrence hazard, patterns, and peak rates varied substantially depending on different risk factors of HCC recurrence.
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| http://dx.doi.org/10.1007/s13304-023-01652-y | DOI Listing |
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