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| http://dx.doi.org/10.1503/cmaj.230014 | DOI Listing |
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Department of Pediatrics, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Article Synopsis
- - The case involves a 2-month-old Iranian boy who developed persistent fever after receiving a 5-in-1 vaccine, leading to a diagnosis of atypical Kawasaki disease, which is rare in infants.
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Protein-losing enteropathy with congenital kidney stones in a 2-month-old boy: a rare case report and literature review.
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Department of Gastroenterology, Kunming Children's Hospital, Kunming, 650000, China.
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View Article and Find Full Text PDFUsing PBPK modeling to supplement clinical data and support the safe and effective use of dolutegravir in pregnant and lactating women.
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Optimal dosing in pregnant and lactating women requires an understanding of the pharmacokinetics in the mother, fetus, and breastfed infant. Physiologically-based pharmacokinetic (PBPK) modeling can be used to simulate untested scenarios and hence supplement clinical data to support dosing decisions. A PBPK model for the antiretroviral dolutegravir (mainly metabolized by UGT1A1) was verified using reported exposures in non-pregnant healthy volunteers, pregnant women, and the umbilical cord, lactating mothers, and breastfed neonates.
View Article and Find Full Text PDFManagement of cloacal exstrophy: Experience from tertiary hospital, Tanzania. Case series.
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Department of Surgery, School of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
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