AI Article Synopsis
- The text discusses a method for adding two functional groups to 1,3-dienes using a photoinduced copper catalyst.
- This process involves generating a selenium atom radical through visible light, which reacts to form an allyl radical intermediate.
- The allyl radical can then quickly isomerize and undergo copper-catalyzed reactions with different nucleophiles, allowing for selective functionalization.
Article Abstract
Described herein is a photoinduced copper-catalyzed 1,2-difunctionalization of 1,3-dienes. The selenium atom radical was generated by the visible light irradiation of diselenides, triggering radical addition with 1,3-dienes to form allyl radical intermediate. Subsequent rapid / isomerization allowed for thermodynamically favorable intermediate formation and enabled copper catalyzed stereoselective functionalization with various nucleophiles.
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| http://dx.doi.org/10.1021/acs.joc.3c01181 | DOI Listing |
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