AI Article Synopsis
- Our research presents a new method for synthesizing 3,4-dihydro-2-benzo[]chromen-2-one and fluorenone derivatives using -alkynylarylketones as starting materials.
- The synthesis of 3,4-dihydro-2-benzo[]chromen-2-ones involves a silver-catalyzed reaction that creates intermediates, which then undergo a series of transformations to produce the final product in one step.
- For fluorenone derivatives, the same precursor is utilized, involving an acid-catalyzed process that leads to the formation of key intermediates, ultimately resulting in good yields of the desired products.
Article Abstract
Our research has led to the development of a divergent synthesis approach for the synthesis of 3,4-dihydro-2-benzo[]chromen-2-one 3 and fluorenone 9 derivatives using -alkynylarylketones as common precursors. The synthesis of 3,4-dihydro-2-benzo[]chromen-2-ones 3 employed silver catalyzed ketonization to form polycarbonyl intermediates which underwent double intramolecular cyclization and decarboxylation to generate a lactone and a phenyl ring in a one-pot fashion. In addition, the same precursor could be used to prepare fluorenone derivatives 9 under acidic conditions. The reaction proceeded the formation of indenone analogs, followed by the generation of the -quinone methide intermediate and intramolecular cyclization to provide the corresponding products in good yields.
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| http://dx.doi.org/10.1039/d3ob01492d | DOI Listing |
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