ATP-responsive Mn(II)-based contrast agent for MRI.

Chem Commun (Camb)

Department of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King's College London, Fourth Floor Lambeth Wing, St Thomas' Hospital, London, SE1 7EH, UK.

Published: November 2023

A novel diacetylpyridylcarbohydrazide-DAPyCOHz-based manganese(II) chelate with dipicolylamine/zinc(II) (DPA/Zn) arms (MnLDPA-Zn2) was developed for adenosine triphosphate (ATP) responsive magnetic resonance imaging (MRI) contrast applications. Compound 2 shows enhanced relaxivity ( = 11.52 mM s) upon selective ATP binding over other phosphates.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10644988PMC
http://dx.doi.org/10.1039/d3cc03430eDOI Listing

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