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Efficacy and Safety of Intravenous Immunoglobulin (IVIg) in Acute Viral Myocarditis in Children: A Systematic Review of Randomized Controlled Trials.
Indian Pediatr
January 2025
Indian Council of Medical Research (ICMR) Advanced Centre for Evidence Based Child Health (ACEBCH) and Department of Pediatrics, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Context: Acute myocarditis is a rare but potentially life-threatening condition in infants and children. While immunosuppressive agents have shown limited effectiveness, intravenous immunoglobulin (IVIg) holds promise as a treatment option.
Objective: To study the efficacy and safety of intravenous immunoglobulin (IVIg) in treating acute viral myocarditis in children.
Repressing cytokine storm-like response in macrophages by targeting the eIF2α-integrated stress response pathway.
Int Immunopharmacol
January 2025
Department of Geriatric Medicine, Qilu Hospital of Shandong University, Shandong University, Jinan, Shandong Province, China. Electronic address:
Cytokine storm is a life-threatening systemic hyper-inflammatory state caused by different etiologies, in which the bulk production of pro-inflammatory cytokines from activated macrophages has a central role. Integrated stress response (ISR) comprises several protective signaling pathways, leading to phosphorylation of eukaryotic initiation factor 2α (eIF2α) and repression of protein translation. Emerging evidence suggests that ISR induction may elicit anti-inflammatory effects.
View Article and Find Full Text PDFToxic epidermal necrolysis induced by COVID-19.
Dermatol Reports
November 2024
Pathology Department, Taibah University, Saudi Arabia.
Toxic epidermal necrolysis (TEN) is a life-threatening acute mucocutaneous syndrome. It is characterized by keratinocyte necrosis and apoptosis, which affect more than 30% of the body's surface. TEN is most commonly due to an altered immunological response to specific drugs, infections, and malignancies, or it can be idiopathic.
View Article and Find Full Text PDFFatal acute uterine inversion post-vaginal delivery: an autopsy-based case report.
Forensic Sci Med Pathol
January 2025
Department of Forensic Medicine and Toxicology, Maharishi Markandeshwar Institute of Medical Sciences and Research, Mullana (Ambala), Haryana, India.
Uterine inversion refers to the condition where the fundus is turned inside and positioned within the uterine cavity. Uterine inversion is a life-threatening and uncommon obstetric emergency that can be fatal because of postpartum hemorrhage and shock. Acute uterine inversion is the most common type, which occurs within 24 h of delivery and is usually associated with untrained birth attendants and a lack of knowledge of labor-inducing drugs.
View Article and Find Full Text PDFA Complex Case of Acute Liver Failure Following Idiosyncratic Drug-Induced Liver Injury, Potentiated by Herpes Simplex Virus Infection.
Cureus
December 2024
Internal Medicine, Unidade Local de Saúde de São José, Lisbon, PRT.
Acute liver failure (ALF) is a rare, life-threatening condition that may be secondary to drug-induced liver injury (DILI) and certain viral infections. We present the case of a 73-year-old male with a history of fibrotic hypersensitivity pneumonitis with a progressive phenotype, type 2 diabetes mellitus, hypertension, and hyperlipidemia, who was admitted with ALF potentially secondary to DILI. Prior to admission, he was receiving therapy that may be related to idiosyncratic DILI (I-DILI) and ALF, namely nintedanib, which appears to have a most probable relation to I-DILI in this case, considering it was the most recently started drug.
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