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Trends in antimicrobial resistance of species in Peru, 2011-2020. | LitMetric

Trends in antimicrobial resistance of species in Peru, 2011-2020.

JAC Antimicrob Resist

Laboratorio de Referencia Nacional de Bacteriología Clínica, Instituto Nacional de Salud, Lima, Perú.

Published: October 2023

AI Article Synopsis

  • The study analyzed 1,668 strains of enteric pathogens collected in Peru over the past 10 years to assess antimicrobial resistance rates and how they changed over time and location.
  • The most commonly identified species were resistant to several antibiotics, with particularly high resistance rates observed for trimethoprim/sulfamethoxazole (91.0%) and tetracycline (88.4%), and a concerning increase in resistance to fluoroquinolones from 2017 to 2020.
  • The findings underline the dominance of a specific species resistant to common antibiotics, raising alarms about increasing resistance and the implications for treatment of infections.

Article Abstract

Objective: To describe the frequency of antimicrobial resistance rates and spatial-temporal distribution of species from the last 10 years in Peru.

Methods: A cross-sectional descriptive study was carried out. A total of 1668 strains, remitted as part of the national enteric pathogen surveillance from 2011 to 2020, were analysed. The strains were confirmed by conventional tests and serotyped with polyvalent and monovalent antibodies. Also, antimicrobial susceptibility was performed according to the Kirby-Bauer method.

Results: The most frequent species was (49.2%), followed by (42.2%), (7.9%) and (0.7%). Phase II (46.29%) was the most frequent serotype in , serotype 2a (43.61%) in , serotype 2 in and serotype 4 in . High rates of resistance were detected for trimethoprim/sulfamethoxazole (91.0%), tetracycline (88.4%), ampicillin (73.9%) and chloramphenicol (64.9%), moderate rates for amoxicillin/clavulanic acid (25.1%), ciprofloxacin (16.7%) and nalidixic acid (14.8%), and low rates for cefotaxime (1.74%), nitrofurantoin (0.7%) and ceftazidime (0.6%). Moreover, antimicrobial resistance to fluoroquinolones increased considerably from 2017 to 2020.

Conclusion: was the most frequent species, which have a large proportion of strains resistant to trimethoprim/sulfamethoxazole, and a growing trend of resistance to ciprofloxacin and nalidixic acid. This increase in resistance to commonly used antibiotics in treatments is alarming, threatening the control and management of these currently treatable infections.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600570PMC
http://dx.doi.org/10.1093/jacamr/dlad110DOI Listing

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