HOXC cluster antisense RNA 3 (HOXC-AS3) is a novel long noncoding RNA (lncRNA) that exhibits aberrant expression patterns in various cancer types. Its expression is closely related to clinicopathological features, demonstrating significant clinical relevance across multiple tumors. And HOXC-AS3 plays multifaceted roles in tumor progression, impacting cell proliferation, apoptosis, migration, invasion, epithelial-mesenchymal transition (EMT), autophagy, senescence, tumor growth, and metastasis. In this review, we summarized and comprehensively analyzed the expression and clinical significance of HOXC-AS3 as a diagnostic and prognostic biomarker for malignancies. Additionally, we presented an in-depth update on HOXC-AS3's functions and regulatory mechanisms in cancer pathogenesis. This narrative review underscores the importance of HOXC-AS3 as a promising lncRNA candidate in cancer research and its potential as a predictive biomarker and therapeutic target in clinical applications.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10612484 | PMC |
| http://dx.doi.org/10.2147/OTT.S425523 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
SET-NUP214-induced hypermethylation landscape promotes abnormal overexpression of HOXC cluster genes in acute megakaryoblastic leukemia.
Genes Dis
March 2025
Pediatric Hematology-Oncology, Department of Pediatrics, Arkansas Children's Research Institute, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA.
Molecular leveraging of HOX-embedded non-coding RNAs in the progression of acute myeloid leukemia.
Hum Cell
November 2024
Department of Medical Oncology, Dr. B.R.A. IRCH, All India Institute of Medical Sciences, Room No. 401, 4th Floor, New Delhi, India.
Acute myeloid leukemia (AML) is characterized by impaired differentiation of myeloid cells leading to hematopoietic failure. Despite advances, the molecular mechanisms driving AML remain incompletely understood, limiting the identification and targeting of critical vulnerabilities in leukemic cells. Homeobox (HOX) genes, encoding transcription factors essential for myeloid and lymphoid differentiation, are distributed across four clusters: HOXA (chromosome 7), HOXB (chromosome 17), HOXC (chromosome 12), and HOXD (chromosome 2).
View Article and Find Full Text PDFExpression Is an Independent Prognostic Biomarker in Esophageal Squamous Cell Carcinoma.
Genes (Basel)
November 2024
Laboratório de Toxicologia e Biologia Molecular, Departamento de Bioquímica, Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro 20550-013, RJ, Brazil.
Article Synopsis
- Homeobox genes are important for organ development and differentiation, and in humans, they are divided into four clusters (HOXA, HOXB, HOXC, HOXD).
- This study focused on the role of these genes in esophageal squamous cell carcinoma (ESCC), finding that while mutations were rare, seven specific homeobox genes were significantly different in ESCC tissues compared to non-cancerous ones.
- The study revealed that these genes' dysregulation may affect cancer pathways and is linked to poor survival rates, suggesting their potential as prognostic biomarkers and targets for new therapies.
The Hox code responsible for the patterning of the anterior vertebrae in zebrafish.
Development
July 2024
Division of Life Science, Graduate School of Science and Engineering, Saitama University, Shimo-Okubo 255, Sakura-ku, Saitama 338-8570, Japan.
The vertebral column is a characteristic structure of vertebrates. Genetic studies in mice have shown that Hox-mediated patterning plays a key role in specifying discrete anatomical regions of the vertebral column. Expression pattern analyses in several vertebrate embryos have provided correlative evidence that the anterior boundaries of Hox expression coincide with distinct anatomical vertebrae.
View Article and Find Full Text PDFGenomic characterization of cervical lymph node metastases in papillary thyroid carcinoma following the Chornobyl accident.
Nat Commun
June 2024
Laboratory of Genetic Susceptibility, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Article Synopsis
- Childhood exposure to radioactive iodine from the Chornobyl accident increases the risk of papillary thyroid carcinoma (PTC), particularly in younger individuals.
- A study of 428 PTC cases found that cervical lymph node metastases (cLNM) were more common in PTC with certain genetic fusions compared to mutations, and this frequency varied significantly by specific gene types.
- Molecular profiling of the cLNM showed strong genetic concordance with primary PTCs and identified 17 differentially expressed genes, pointing to potential biological mechanisms in PTC metastasis that require further investigation.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!