AI Article Synopsis
- The study examined the effects of new-onset atrial fibrillation (AF) on patients hospitalized for COVID-19, particularly looking at those over 55 years old.
- A total of 668 patients were analyzed, revealing that those with new-onset AF had more comorbid conditions and faced higher rates of complications like major bleeding and cardiovascular mortality compared to patients without AF.
- The findings suggest that while new-onset AF in COVID-19 patients may lead to worse health outcomes, the severity of these outcomes was also influenced by the dosage of anticoagulants administered.
Article Abstract
Objective: To assess the impact of new-onset atrial fibrillation (AF) on patients hospitalized with coronavirus disease 2019 (COVID-19).
Methods: Multicenter and retrospective study that included subjects >55 years hospitalized with COVID-19 from March to October 2020 in Spanish hospitals. Patients were divided into 3 groups (no AF, new-onset AF, and preexisting AF) and followed-up to 90 days.
Results: A total of 668 patients were included, of whom 162 (24.3%) had no AF, 107 (16.0%) new-onset AF and 399 (59.7%) preexisting AF. Compared to patients without AF, those patients with new-onset AF were older and had more comorbidities, but without differences with preexisting AF. During hospitalization, in the univariate analysis, compared to patients without AF, major bleeding and cardiovascular mortality were more frequent in patients with new-onset AF (10.3% vs 0.6%; < .001; 2.8% vs 0.6%; = .025, respectively), with a trend toward more stroke (1.9% vs 0%; = .085). Outcomes were similar between AF groups, but the length of stay was greater in preexisting AF patients. Among patients with new-onset AF taking reduced doses of anticoagulant treatment was associated with higher risks of stroke and major bleeding.
Conclusions: In COVID-19 hospitalized patients, new-onset AF may be associated with worse outcomes, but influenced by the dose of anticoagulants.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617267 | PMC |
| http://dx.doi.org/10.1177/10760296231208440 | DOI Listing |
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