AI Article Synopsis
- Allergic bronchopulmonary aspergillosis (ABPA) and chronic pulmonary aspergillosis (CPA) are related diseases caused by Aspergillus infection, with CPA sometimes developing from ABPA.
- A case study reported on a patient experiencing both conditions concurrently and monitored serum cytokine levels at various stages of treatment.
- The study found that IL-13 levels decreased with glucocorticoid treatment, while IL-25 and IL-33 levels dropped quickly after starting antifungal medications, suggesting early antifungal treatment is crucial for managing disease progression and preventing overlap of CPA.
Article Abstract
Allergic bronchopulmonary aspergillosis (ABPA) and chronic pulmonary aspergillosis (CPA) are diseases caused by Aspergillus infection, and CPA can develop from ABPA in some cases. We herein report a patient with CPA overlapping with ABPA. Serum cytokine levels were evaluated at 4 time points: the ABPA diagnosis, CPA diagnosis, 6 months after the start of voriconazole (VRCZ), and 12 months after re-administration of VRCZ. Interleukin (IL)-13 levels decreased upon glucocorticoid treatment, whereas IL-25 and IL-33 levels decreased rapidly with the initiation of antifungals. Early antifungal therapy may be important to control disease progression and prevent CPA overlap.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11189703 | PMC |
| http://dx.doi.org/10.2169/internalmedicine.2234-23 | DOI Listing |
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