AI Article Synopsis
- Clostridioides difficile infection (CDI) is a major cause of diarrhea in hospitals across North America and Europe, leading to significant health risks.
- Previous risk factors don't fully explain why some people get CDI while others don't, suggesting a genetic component to susceptibility.
- A study involving nearly 20,000 participants found that variations in the DRB locus of the MHC (HLA) II region may increase the likelihood of developing CDI, indicating that genetic factors could influence how the body responds to this infection.
Article Abstract
Clostridioides difficile (C. diff.) infection (CDI) is a leading cause of hospital acquired diarrhea in North America and Europe and a major cause of morbidity and mortality. Known risk factors do not fully explain CDI susceptibility, and genetic susceptibility is suggested by the fact that some patients with colons that are colonized with C. diff. do not develop any infection while others develop severe or recurrent infections. To identify common genetic variants associated with CDI, we performed a genome-wide association analysis in 19,861 participants (1349 cases; 18,512 controls) from the Electronic Medical Records and Genomics (eMERGE) Network. Using logistic regression, we found strong evidence for genetic variation in the DRB locus of the MHC (HLA) II region that predisposes individuals to CDI (P > 1.0 × 10; OR 1.56). Altered transcriptional regulation in the HLA region may play a role in conferring susceptibility to this opportunistic enteric pathogen.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613277 | PMC |
| http://dx.doi.org/10.1038/s41598-023-45649-4 | DOI Listing |
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