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http://dx.doi.org/10.1016/j.jlr.2023.100467 | DOI Listing |
J Lipid Res
December 2023
Department of Medicine, University of California, Los Angeles, CA, USA; Department of Human Genetics, University of California, Los Angeles, CA, USA. Electronic address:
J Lipid Res
May 2022
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA. Electronic address:
Triglycerides (TG) are required for fatty acid transport and storage and are essential for human health. Angiopoietin-like-protein 8 (ANGPTL8) has previously been shown to form a complex with ANGPTL3 that increases circulating TG by potently inhibiting LPL. We also recently showed that the TG-lowering apolipoprotein A5 (ApoA5) decreases TG levels by suppressing ANGPTL3/8-mediated LPL inhibition.
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