AI Article Synopsis
- The study identified new RNA viruses (ClRNAV1, ClRNAV2, HeRNAV1) in trematodes that infect sea snails.
- These viruses belong to different families and replicate in specific stages of the trematode life cycle.
- The potential for "trematode rabies" raises possibilities for using genetically modified viruses in controlling trematode-related diseases.
Article Abstract
This study characterized novel RNA viruses, parasites of parasites, or hyperparasites identified during transcriptomic analyses of two trematode species, Cryptocotyle lingua and Himasthla elongata, infecting a sea snail, Littorina littorea. According to the viral genome structures and phylogenetic analysis, Cryptolin alternavirus (ClRNAV1), Cryptolin calicivirus (ClRNAV2) and Himastelon rhabdovirus 1 (HeRNAV1) were respectively classified within the families Alternaviridae, Caliciviridae and Rhabdoviridae. They replicate species-specifically in two studied phases of trematode live cycle: intramolluscan parthenogenetic rediae and free-swimming cercariae. ClRNAV1 showed significantly higher expression in C. lingua cercariae relative to rediae. HeRNAV1's similarity to rabies viruses raises questions about its potential effects on the nervous system of H. elongata. This 'trematode rabies' could enable the use of genetically modified viruses for developing new methods to control the spread and intensity of diseases caused by trematodes.
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| http://dx.doi.org/10.1016/j.jip.2023.108012 | DOI Listing |
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