Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.urology.2023.10.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Few-Layer Graphene-Based Optical Nanobiosensors for the Early-Stage Detection of Ovarian Cancer Using Liquid Biopsy and an Active Learning Strategy.
Cells
March 2025
Department of Cancer Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Ovarian cancer survival depends strongly on the time of diagnosis. Detection at stage 1 must be the goal of liquid biopsies for ovarian cancer detection. We report the development and validation of graphene-based optical nanobiosensors (G-NBSs) that quantify the activities of a panel of proteases, which were selected to provide a crowd response that is specific for ovarian cancer.
View Article and Find Full Text PDFUnusual Cardiovascular Response to Sildenafil: Complete Heart Block in a Healthy Young Adult.
Cureus
February 2025
Emergency Medicine, Charnock Hospital, Kolkata, IND.
Sildenafil, a phosphodiesterase-5 (PDE5) inhibitor, is widely used for erectile dysfunction and pulmonary hypertension, with its cardiovascular safety profile being well documented. However, its potential to induce conduction abnormalities remains largely unexplored, both due to a lack of clinical reports and limited mechanistic studies. While tachyarrhythmias have been frequently associated with sildenafil use, bradyarrhythmias, particularly complete heart block, are an unreported complication.
View Article and Find Full Text PDFMonitoring the mitochondrial localization of mycobacterial proteins.
Methods Cell Biol
March 2025
Department of Biochemistry, School of Life Sciences, University of Hyderabad, India. Electronic address:
Mitochondrion apart from being the energy hub of the cell, is also the center of various signaling pathways. During intracellular infection, either bacterial or viral, several pathogen proteins, metabolites, and possibly, lipids interact with the host mitochondria. These interactions allow the pathogens, such as Mtb, to reprogram the host mitochondrial functions, screwing the host immune responses and resulting in the persistence of the bacteria.
View Article and Find Full Text PDFStimulation of auricular vagus nerve ameliorates chronic stress induced metabolic syndrome via activation of Sirtuin-6.
Biochem Biophys Res Commun
March 2025
Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, (A Central University), Vidya Vihar, Raebareli Road, Lucknow, 226 025, (U.P.), India. Electronic address:
Chronic stress is one of the potential causes of the progression of metabolic syndrome (MS). Chronic stress decreases the release of Sirtuin-6 (SIRT6), which regulates MS by controlling glucose, insulin, lipids, and hypertension. Vagus nerve stimulation (VNS) activates SIRT6 via the cholinergic anti-inflammatory pathway (CAP).
View Article and Find Full Text PDFPharmacokinetics and Pharmacodynamics of KT-474, a Novel Selective Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) Degrader, in Healthy Adults.
Clin Transl Sci
March 2025
Kymera Therapeutics, Inc., Watertown, Massachusetts, USA.
Interleukin-1 receptor-associated kinase 4 (IRAK4), a key component of the Myddosome complex, mediates signaling through toll-like and interleukin-1 receptors. KT-474, a heterobifunctional IRAK4 degrader, was evaluated in a randomized, double-blind, placebo-controlled Phase 1 trial (NCT04772885) in single (25, 75, 150, 300, 600, 1000, and 1600 mg) and multiple (25, 50, 100, and 200 mg once daily [QD] for 14 days; or 200 mg twice weekly) ascending doses in healthy subjects. The pharmacokinetics of KT-474 and its diastereomers, the pharmacodynamics of KT-474, and the effect of food on KT-474 pharmacokinetics and the pharmacokinetic-pharmacodynamic analysis are presented as additional analyses to supplement the Ackerman et al.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!