ViralZone (http://viralzone.expasy.org) is a knowledge repository for viruses that links biological knowledge and databases. It contains data on virion structure, genome, proteome, replication cycle and host-virus interactions. The new update provides better access to the data through contextual popups and higher resolution images in Scalable Vector Graphics (SVG) format. These images are designed to be dynamic and interactive with human viruses to give users better access to the data. In addition, a new coronavirus-specific resource provides regularly updated data on variants and molecular biology of SARS-CoV-2. Other virus-specific resources have been added to the database, particularly for HIV, herpesviruses and poxviruses.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10767872 | PMC |
| http://dx.doi.org/10.1093/nar/gkad946 | DOI Listing |
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An early precursor CD8 T cell that adapts to acute or chronic viral infection.
Nature
January 2025
Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
This study examines the origin and differentiation of stem-like CD8+ T cells that are essential for sustained T cell immunity in chronic viral infections and cancer and also play a key role in PD-1 directed immunotherapy. These PD-1+ TCF-1+ TOX+ stem-like CD8+ T cells, also referred to as precursors of exhausted T cells, have a distinct program that allows them to adapt to chronic antigen stimulation. Using the mouse model of chronic LCMV infection we found that virus specific stem-like CD8+ T cells are generated early (day 5) during chronic infection suggesting that this crucial fate commitment occurs irrespective of infection outcome.
View Article and Find Full Text PDFRT-RPA as a dual tool for detection and phylogenetic analysis of epidemic arthritogenic alphaviruses.
Sci Rep
December 2024
Rutgers Global Health Institute, Rutgers University, New Brunswick, NJ, USA.
Chikungunya (CHIKV), o'nyong-nyong (ONNV), and Mayaro (MAYV) viruses are transmitted by mosquitoes and known to cause a debilitating arthritogenic syndrome. These alphaviruses have emerged and re-emerged, leading to outbreaks in tropical and subtropical regions of Asia, South America, and Africa. Despite their prevalence, there persists a critical gap in the availability of sensitive and virus-specific point-of-care (POC) diagnostics.
View Article and Find Full Text PDFMolecular Diversity and Distribution of Whiteflies () in Cassava Fields Across South West and North Central, Nigeria.
Insects
November 2024
Regional Center of Excellence for Transboundary Plant Pathogens, Central and West African Virus Epidemiology (WAVE), Pôle Scientifique et d'Innovation, Université Félix Houphouët-Boigny, Abidjan BPV 34, Côte d'Ivoire.
Whitefly (Gennadium, Hemiptera) causes severe damage to cassava plants through excessive feeding on leaves and transmitting viruses, such as (ACMV), (EACMV), and ipomoviruses that cause cassava brown streak disease. Currently, little is known about the molecular diversity and distribution of whitefly species in the major cassava-growing zones of Nigeria. This study aimed to address the knowledge gap by assessing the genetic diversity, distribution, and associated cassava mosaic begomoviruses (CMBs) in whiteflies across South West and North Central, Nigeria.
View Article and Find Full Text PDFPerformance evaluation of TaqMan™ Arbovirus Triplex Kit (ZIKV/DENV/CHIKV) for detection and differentiation of dengue and chikungunya viral RNA in serum samples of symptomatic patients.
J Virol Methods
February 2025
Dept. of Clinical Virology, Christian Medical College, Vellore, Tamil Nadu, India. Electronic address:
Introduction: Global outbreaks of mosquito-transmitted arbovirus infections, such as dengue (DENV) and chikungunya (CHIKV), are increasing. Differentiating these infections is challenging due to non-specific symptoms and serology limitations. PCR-based approaches offer higher sensitivity and specificity.
View Article and Find Full Text PDFArticle Synopsis
- Chronic infections can lead to CD8 T cell exhaustion, which diminishes their ability to fight infections, but the role of metabolites in this process is not fully understood.
- Researchers used a virus model in mice to analyze metabolite changes during acute and chronic infections, finding notable differences in nutrients, especially during the early phase of chronic infection.
- The study highlights the importance of long-chain fatty acids in affecting T cell function and metabolism, providing insights into potential strategies for improving immune responses during prolonged infections.
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