AI Article Synopsis
- * Exercise promotes the release of endocannabinoids and kynurenines, which can provide benefits such as reducing anxiety, pain, inflammation, and oxidative stress.
- * This review aims to explore recent studies on how these two systems interact during exercise, suggesting that regular physical activity could be a novel treatment strategy for managing depression and obesity.
Article Abstract
The kynurenine pathway (KP) and the endocannabinoid system (ECS) are known to be deregulated in depression and obesity; however, it has been recognized that acute physical exercise has an important modulating role inducing changes in the mobilization of their respective metabolites-endocannabinoids (eCBs) and kynurenines (KYNs)-which overlap at some points, acting as important antidepressant, anti-nociceptive, anti-inflammatory, and antioxidant biomarkers. Therefore, the aim of this review is to analyze and discuss some recently performed studies to investigate the potential interactions between both systems, particularly those related to exercise-derived endocannabinoidome and kynurenine mechanisms, and to elucidate how prescription of physical exercise could represent a new approach for the clinical management of these two conditions.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10609722 | PMC |
| http://dx.doi.org/10.3390/ph16101421 | DOI Listing |
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Crosstalk between Exercise-Derived Endocannabinoidome and Kynurenines: Potential Target Therapies for Obesity and Depression Symptoms.
Pharmaceuticals (Basel)
October 2023
Neuromuscular Diseases Laboratory, Clinical Neurosciences Division, National Institute of Rehabilitation "Luis Guillermo Ibarra Ibarra", Mexico City 14389, Mexico.
Article Synopsis
- * Exercise promotes the release of endocannabinoids and kynurenines, which can provide benefits such as reducing anxiety, pain, inflammation, and oxidative stress.
- * This review aims to explore recent studies on how these two systems interact during exercise, suggesting that regular physical activity could be a novel treatment strategy for managing depression and obesity.
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