The effects of Mn addition on the room temperature tensile strength and deformation mechanisms of as-cast Mg-8Al-1Nd-1.5Gd-Mn alloys ( = 0, 0.3, 0.5, 1.0 wt.%) are investigated in this paper. The results indicate that the addition of Mn contributes to the precipitation of Al-Mn-RE intermetallics and the refinement of -Mg matrices, thereby improving the tensile strength of the 1.0 Mn alloy at 190 MPa. The fracture mechanism of Mn-containing alloys transforms from a cleavage fracture to a ductile fracture as the Mn content increases from 0.3 to 1.0 wt.%. The presence of intermetallic particles in the dimples confirms the hindrance effect of AlMn (Nd,Gd) on dislocation slips. The novel technology of in-grain misorientation axes (IGMAs) is used to identify activated slip modes and deformation twins. It can be concluded that the activated pyramidal slip during tensile deformation significantly promotes the ductility of the 1.0 Mn alloy with an elongation rate of 9.8%. It is worth noting that reducing the coarse 101¯2 tensile twins and enhancing the proportion of 101¯1 compressive twins and 101¯1-101¯2 double twins contributes to maintaining the continuous plastic deformation of Mg alloy.
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http://dx.doi.org/10.3390/ma16206747 | DOI Listing |
Exp Brain Res
January 2025
Faculty of Sport, Technology and Health Sciences, St. Mary's University, Twickenham, Middlesex, UK.
The aim of this study was to assess if ischaemic preconditioning (IPC) can reduce pain perception and enhance corticospinal excitability during voluntary contractions. In a randomised, within-subject design, healthy participants took part in three experimental visits after a familiarisation session. Measures of pressure pain threshold (PPT), maximum voluntary isometric force, voluntary activation, resting twitch force, corticospinal excitability and corticospinal inhibition were performed before and ≥10 min after either, unilateral IPC on the right leg (3 × 5 min); a sham protocol (3 × 1 min); or a control (no occlusion).
View Article and Find Full Text PDFCell Rep
January 2025
Department of Clinical Neurological Sciences, London Health Sciences Centre, Western University, London, ON, Canada; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada; Western Institute for Neuroscience, Western University, London, ON, Canada.
Cortical neurons in brain slices display intrinsic spike frequency adaptation (I-SFA) to constant current inputs, while extracellular recordings show extrinsic SFA (E-SFA) during sustained visual stimulation. Inferring how I-SFA contributes to E-SFA during behavior is challenging due to the isolated nature of slice recordings. To address this, we recorded macaque lateral prefrontal cortex (LPFC) neurons in vivo during a visually guided saccade task and in vitro in brain slices.
View Article and Find Full Text PDFMaterials (Basel)
December 2024
Department of Marine Design Convergence Engineering, Pukyong National University, 45 Yongso-ro, Nam-gu, Busan 48513, Republic of Korea.
Controlling microstructure and texture development is a key approach to improving the formability of magnesium alloys. In this study, the effects of the strain rate and initial texture on the texture evolution of magnesium alloys during high-temperature processing are investigated. The plane strain compression of three types of AZ80 magnesium alloys with different initial textures was assessed at 723 K and a train rate of 0.
View Article and Find Full Text PDFGenes (Basel)
December 2024
Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, USA.
Background: (absent, small, or homeotic-like 1), a histone methyltransferase, has been identified as a high-risk gene for autism spectrum disorder (ASD). We previously showed that postnatal severe deficiency in the prefrontal cortex (PFC) of male and female mice caused seizures. However, the synaptic mechanisms underlying autism-like social deficits and seizures need to be elucidated.
View Article and Find Full Text PDFElife
January 2025
Department of Neurology, Baylor College of Medicine, Houston, United States.
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