Global Health Neurology Lab, Sydney, NSW 2150, Australia.
Published: September 2023
AI Article Synopsis
Article Abstract
Background: Futile recanalization (FR) continues to raise concern despite the success of endovascular thrombectomy (EVT) in acute ischemic stroke (AIS). Understanding the prevalence of FR and identifying associated factors are crucial for refining patient prognoses and optimizing management strategies.
Objectives: This study aims to comprehensively assess the pooled prevalence of FR, explore the diverse factors connected with FR, and establish the association of FR with long-term clinical outcomes among AIS patients undergoing EVT.
Materials And Methods: Incorporating studies focusing on FR following EVT in AIS patients, we conducted a random-effect meta-analysis to assess the pooled prevalence and its association with various clinical and imaging risk factors linked to FR. Summary estimates were compiled and study heterogeneity was explored.
Results: Our comprehensive meta-analysis, involving 11,700 AIS patients undergoing EVT, revealed a significant pooled prevalence of FR at 51%, with a range of 48% to 54% (Effect Size [ES]: 51%; 95% Confidence Interval [CI]: 48-54%; z = 47.66; < 0.001). Numerous clinical factors demonstrated robust correlations with FR, including atrial fibrillation (Odds Ratio [OR]: 1.39, 95% CI 1.22 1.59; < 0.001), hypertension (OR 1.65, 95% CI 1.41 1.92; < 0.001), diabetes mellitus (OR 1.71, 95% CI 1.47 1.99; < 0.001), previous stroke or transient ischemic attack (OR 1.298, 95% CI 1.06 1.59; = 0.012), prior anticoagulant usage (OR 1.33, 95% CI 1.08 1.63; = 0.007), cardioembolic strokes (OR 1.34, 95% CI 1.10 1.63; = 0.003), and general anesthesia (OR 1.53, 95% CI 1.35 1.74; < 0.001). Conversely, FR exhibited reduced likelihoods of smoking (OR 0.66, 95% CI 0.57 0.77; < 0.001), good collaterals (OR 0.33, 95% CI 0.23 0.49; < 0.001), male sex (OR 0.87, 95% CI 0.77 0.97; = 0.016), and intravenous thrombolysis (IVT) (OR 0.75, 95% CI 0.66 0.86; < 0.001). FR was strongly associated with increasing age (standardized mean difference [SMD] 0.49, 95% CI 0.42 0.56; < 0.0001), baseline systolic blood pressure (SMD 0.20, 95% CI 0.13 0.27; < 0.001), baseline National Institute of Health Stroke Severity Score (SMD 0.75, 95% CI: 0.65 0.86; < 0.001), onset-to-treatment time (SMD 0.217, 95% CI 0.13 0.30; < 0.001), onset-to-recanalization time (SMD 0.38, 95% CI 0.19; 0.57; < 0.001), and baseline blood glucose (SMD 0.31, 95% CI 0.22 0.41; < 0.001), while displaying a negative association with reduced baseline Alberta Stroke Program Early CT Score (ASPECTS) (SMD -0.37, 95% CI -0.46 -0.27; < 0.001). Regarding clinical outcomes, FR was significantly associated with increased odds of symptomatic intracranial hemorrhages (OR 7.37, 95% CI 4.89 11.12; < 0.001), hemorrhagic transformations (OR 2.98, 95% CI 2.37 3.75; < 0.001), and 90-day mortality (OR 19.24, 95% CI 1.57 235.18; = 0.021).
Conclusions: The substantial prevalence of FR, standing at approximately 51%, warrants clinical consideration. These findings underscore the complexity of FR in AIS patients and highlight the importance of tailoring management strategies based on individual risk factors and clinical profiles.
The study measured fibrinogen fluorescence at temperatures between 20 and 80 degrees Celsius across different pH levels.
It was found that raising the temperature from 20 to 40 degrees Celsius did not change the structure of fibrinogen in solutions with pH between 4.5 and 9.3.
However, temperatures between 40 to 50 degrees Celsius caused some structural changes in neutral solutions, and temperatures above 50-55 degrees Celsius led to significant denaturation of the fibrinogen molecule.
