AI Article Synopsis

  • Chemotherapy is a standard treatment for colorectal cancer but often faces issues with drug resistance, prompting the need for new drug developments.
  • Recent studies show that neocryptolepine derivatives, particularly MMNC, have significant cytotoxic effects on colorectal cancer cells such as HCT116 and Caco-2.
  • MMNC inhibits cell proliferation, induces apoptosis, and affects the cell cycle while targeting the PI3K/AKT/mTOR signaling pathway, marking it as a promising candidate for colorectal cancer treatment.

Article Abstract

Chemotherapy is commonly used clinically to treat colorectal cancer, but it is usually prone to drug resistance, so novel drugs need to be developed continuously to treat colorectal cancer. Neocryptolepine derivatives have attracted a lot of attention because of their good cytotoxic activity; however, cytotoxicity studies on colorectal cancer cells are scarce. In this study, the cytotoxicity of 8-methoxy-2,5-dimethyl-5H-indolo[2,3-b] quinoline (MMNC) in colorectal cells was evaluated. The results showed that MMNC inhibits the proliferation of HCT116 and Caco-2 cells, blocks the cell cycle in the G2/M phase, decreases the cell mitochondrial membrane potential and induces apoptosis. In addition, the results of western blot experiments suggest that MMNC exerts cytotoxicity by inhibiting the expression of PI3K/AKT/mTOR signaling pathway-related proteins. Based on these results, MMNC is a promising lead compound for anticancer activity in the treatment of human colorectal cancer.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606936PMC
http://dx.doi.org/10.3390/ijms242015142DOI Listing

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