AI Article Synopsis
- Resiniferatoxin (RTX) is a powerful analog of capsaicin that effectively desensitizes pain and inflammation without serious side effects.
- RTX has shown promising results in restoring bladder control and permanently alleviating pain by targeting sensory neurons, making it a potential game-changer for cancer pain management.
- Clinical trials are also exploring RTX's use for treating knee pain in osteoarthritis and possibly managing post-operative pain and severe burn injuries.
Article Abstract
Resiniferatoxin (RTX) is an ultrapotent capsaicin analog with a unique spectrum of pharmacological actions. The therapeutic window of RTX is broad, allowing for the full desensitization of pain perception and neurogenic inflammation without causing unacceptable side effects. Intravesical RTX was shown to restore continence in a subset of patients with idiopathic and neurogenic detrusor overactivity. RTX can also ablate sensory neurons as a "molecular scalpel" to achieve permanent analgesia. This targeted (intrathecal or epidural) RTX therapy holds great promise in cancer pain management. Intra-articular RTX is undergoing clinical trials to treat moderate-to-severe knee pain in patients with osteoarthritis. Similar targeted approaches may be useful in the management of post-operative pain or pain associated with severe burn injuries. The current state of this field is reviewed, from preclinical studies through veterinary medicine to clinical trials.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606200 | PMC |
| http://dx.doi.org/10.3390/ijms242015042 | DOI Listing |
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