AI Article Synopsis
- - This study analyzed the effects of different techniques for pulmonary artery (PA) reconstruction during lobectomy in lung cancer patients at a hospital in Montpellier, focusing on lung perfusion and lung function post-surgery.
- - Out of 81 patients, 48 had their lung function compared before and after surgery, while 28 had their lung perfusion assessed, revealing no significant differences regardless of the reconstruction technique used.
- - The findings indicate that lobectomy with PA reconstruction maintains lung perfusion and respiratory function, achieving a high patency rate and a 5-year survival rate of 49% over a follow-up of about 34 months.
Article Abstract
Background: The aim of this single-center retrospective cohort study was to assess the impact of arterial reconstruction technique on lung perfusion. The second objective was to ascertain the functional validity of arterial sleeve lobectomy.
Method: Between January 2001 and December 2020, a total of 81 patients underwent lobectomy with pulmonary artery (PA) reconstruction for lung cancer at the University Hospital of Montpellier. After excluding patients with an incomplete postoperative pulmonary function test, we conducted a comparative analysis of the preoperative and postoperative functional outcomes (FEV) of 48 patients, as well as the preoperative and postoperative Technetium99m scintigraphic pulmonary perfusion results of 28 patients. Then, we analyzed postoperative perfusion results according to the pulmonary artery reconstruction techniques use.
Results: PA reconstruction types were as follows: 9 direct angioplasties (19%), 14 patch angioplasties (29%), 7 end-to-end anastomoses (15%), 6 prosthetic bypasses (12%), 11 arterial allograft bypasses (23%), and 1 custom-made xenopericardial conduit bypass. Regardless of the type of vascular reconstruction performed, the comparative analysis of lung perfusion revealed no significant difference between the preoperative and postoperative perfusion ratio of the remaining parenchyma (median = 29.5% versus 32.5%, respectively; = 0.47). Regarding the pulmonary functional test, postoperative predicted FEV significantly underestimated the actual postoperative measured FEV by about 260 mL (11.4%) of the preoperative value. The patency rate was 96% and the 5-year overall survival was 49% for a mean follow up period of 34 months.
Conclusion: Lobectomy with PA reconstruction is a valid parenchymal-sparing technique in terms of perfusion and respiratory function.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605934 | PMC |
| http://dx.doi.org/10.3390/cancers15204971 | DOI Listing |
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