The Immune System Response to in Neurological Diseases.

Previous studies have reported an association between oral microbial dysbiosis and the development and progression of pathologies in the central nervous system. (), the keystone pathogen of the oral cavity, can induce a systemic antibody response measured in patients' sera using enzyme-linked immunosorbent assays. The present case-control study quantified the immune system's response to abundance in the oral cavities of patients affected by different central nervous system pathologies. The study cohort included 87 participants: 23 healthy controls (HC), 17 patients with an acute neurological condition (N-AC), 19 patients with a chronic neurological condition (N-CH), and 28 patients with neurodegenerative disease (N-DEG). The results showed that the abundance in the oral cavity was higher in the N-DEG patients than in the HC ( = 0.0001) and N-AC patients ( = 0.01). In addition, the abundance was higher in the N-CH patients than the HCs ( = 0.005). Only the N-CH patients had more serum anti- antibodies than the HC ( = 0.012). The inadequate response of the immune system of the N-DEG group in producing anti- antibodies was also clearly indicated by an analysis of the ratio between the anti- antibodies quantity and the abundance. Indeed, this ratio was significantly lower between the N-DEG group than all other groups ( = 0.0001, = 0.002, and = 0.03 for HC, N-AC, and N-CH, respectively). The immune system's response to abundance in the oral cavity showed a stepwise model: the response diminished progressively from the patients affected with an acute condition to the patients suffering from chronic nervous system disorders and finally to the patients affected by neurodegenerative diseases.