Oral squamous cell carcinoma (OSCC) accounts for about 95% of oral cancers. It represents a serious public health problem due to the high degree of morbidity and mortality, as well as multifactorial etiology. Human papillomavirus (HPV) infection is a well-documented risk factor for oropharyngeal carcinoma, but its role in oral carcinogenesis is still debatable. Our aim was to investigate the differences in the prevalence of high-risk HPV genotypes (HR-HPV) in patients with OSCC and oral potentially malignant disorders (OPMD) from that of healthy subjects. A total of 90 subjects were included in the cross-sectional study and divided into three groups of 30 patients each: (1) patients with OSCC, (2) patients with OPMD, and (3) healthy subjects. We examined the presence of 12 HR-HPV genotypes in the obtained biological material (oral swabs) using real-time PCR. One or more of the 12 tested HR-HPV genotypes were detected in 5/30 patients with OSCC and 2/30 with OPMD, whereas no healthy subjects were positive for any of the tested genotypes. There was a statistically significant difference in nodal involvement between HPV-positive and HPV-negative patients with OSCC. Oral HR-HPV was detected in patients with oral premalignant and malignant lesions but not in healthy individuals, suggesting a possible role in oral carcinogenesis. Broad HR-HPV panel testing could increase the sensitivity of risk assessment and screening for OSCC.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608774 | PMC |
| http://dx.doi.org/10.3390/medicina59101843 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Lymph node metastasis in level IIb neck dissection for clinically node-negative oral squamous cell carcinoma patients: an 11-year retrospective study.
Int J Oral Maxillofac Surg
January 2025
Service de Chirurgie Maxillo-Faciale et Stomatologie, Université de Bordeaux, CHU Bordeaux, Bordeaux, France. Electronic address:
The most common complication associated with selective neck dissection is spinal accessory nerve dysfunction and shoulder disability, which result from level IIb dissection. The main objective of this study was to evaluate the incidence of level IIb lymph node metastasis in clinically node-negative (cN0) oral squamous cell carcinoma (OSCC) patients. Patients presenting with cN0 OSCC between November 2012 and November 2023 were included retrospectively.
View Article and Find Full Text PDFDiagnosis of lymph node metastasis in oral squamous cell carcinoma by an MRI-based deep learning model.
Oral Oncol
January 2025
Department of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Province Key Laboratory of Stomatology, Guangzhou, Guangdong, China. Electronic address:
Background: Cervical lymph node metastasis (LNM) is a well-established poor prognosticator of oral squamous cell carcinoma (OSCC), in which occult metastasis is a subtype that makes prediction challenging. Here, we developed and validated a deep learning (DL) model using magnetic resonance imaging (MRI) for the identification of LNM in OSCC patients.
Methods: This retrospective diagnostic study developed a three-stage DL model by 45,664 preoperative MRI images from 723 patients in 10 Chinese hospitals between January 2015 and October 2020.
Transferrin receptor uptakes iron from tumor-associated neutrophils to regulate invasion patterns of OSCC.
Cancer Immunol Immunother
January 2025
Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Research Institute of Stomatology, Nanjing University, Nanjing, China.
Background: Transferrin receptor (TFRC) uptakes iron-loaded transferrin (TF) to acquire iron and regulates tumor development. Nonetheless, the clinical values and the precise functions of TF-TFRC axis in the development of oral squamous cell carcinoma (OSCC) were still undiscovered, especially the impacts of their regional heterogeneous expression.
Methods: Immunohistochemistry (IHC) was used to analyze the expression of TFRC in 106 OSCC patients.
A Digital Workflow for Automated Assessment of Tumor-Infiltrating Lymphocytes in Oral Squamous Cell Carcinoma Using QuPath and a StarDist-Based Model.
Pathologica
December 2024
Department of Medicine and Health Sciences "V. Tiberio", University of Molise, Campobasso, Italy.
The search for reliable prognostic markers in oral squamous cell carcinoma (OSCC) remains a critical need. Tumor-infiltrating lymphocytes (TILs), particularly T lymphocytes, play a pivotal role in the immune response against tumors and are strongly correlated with favorable prognoses. Computational pathology has proven highly effective for histopathological image analysis, automating tasks such as cell detection, classification, and segmentation.
View Article and Find Full Text PDFDNA methylation analysis from oral brushing reveals a field cancerization effect in proliferative verrucous leukoplakia.
Pathologica
December 2024
Functional and Molecular Neuroimaging Unit, Bellaria Hospital, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Objectives: The aim of the present study was to analyze the methylation status in patients who presented with an Oral Squamous Cell Carcinoma (OSCC) concomitantly with multifocal Proliferative Verrucous Leukoplakia (PVL)(PVL-OSCC).
Methods: Nine patients with OSCC and concomitant PVL lesions were selected. Two brushing samples were collected simultaneously from OSCC and PVL lesions in contralateral mucosa from each patient.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!