AI Article Synopsis
- Colorectal cancer (CRC) remains a significant public health challenge, prompting a study to assess classic and lesser-known histopathological factors affecting prognosis.
- A retrospective analysis of 71 CRC patients who had surgery focused on both traditional prognostic factors and new parameters like tumor budding, poorly differentiated clusters, and tumor-infiltrating lymphocytes.
- Findings revealed that various high-risk indicators, including deep invasion and certain tumor configurations, are linked to increased chances of lymph node metastases, emphasizing the importance of both established and novel factors in predicting CRC outcomes.
Article Abstract
: Colorectal cancer (CRC) continues to be an essential public health problem. Our study aimed to evaluate the prognostic significance of classic prognostic factors and some less-studied histopathological parameters in CRC. : We performed a retrospective study on 71 colorectal carcinoma patients who underwent surgery at the "Pius Brînzeu" County Clinical Emergency Hospital in Timișoara, Romania. We analyzed the classic parameters but also tumor budding (TB), poorly differentiated clusters (PDCs) of cells, tumor-infiltrating lymphocytes (TILs), and the configuration of the tumor border on hematoxylin-eosin slides. : A high degree of malignancy ( = 0.006), deep invasion of the intestinal wall ( = 0.003), an advanced stage of the disease ( < 0.0001), lymphovascular invasion ( < 0.0001), perineural invasion ( < 0.0001), high-grade TB ( < 0.0001), high-grade PDCs ( < 0.0001), infiltrative tumor border configuration ( < 0.0001) showed a positive correlation with lymph node metastases. : The analyzed parameters positively correlate with unfavorable prognostic factors in CRC. We highlight the value of classic prognostic factors along with a series of less-known parameters that are more accessible and easier to evaluate using standard staining techniques and that could predict the risk of relapse or aggressive evolution in patients with CRC.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608479 | PMC |
| http://dx.doi.org/10.3390/medicina59101761 | DOI Listing |
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