AI Article Synopsis
- Chronic ocular graft-versus-host disease (oGVHD) commonly arises after allogeneic hematopoietic stem cell transplantation, leading to serious eye issues like inflammation and dry eye that can result in corneal perforation.
- A 47-year-old female patient experienced severe symptoms, including dryness and blurred vision, which were diagnosed as graft-versus-host disease with corneal descemetocele in her left eye.
- Multi-layer amniotic membrane transplantation successfully improved her symptoms, providing relief and time to prepare for potential corneal transplantation.
Article Abstract
: Chronic ocular graft-versus-host disease (oGVHD) is a common ocular complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT), characterized by progressive inflammation of the ocular surface and refractory dry eye. In severe cases, sterile corneal perforation can occur, which poses a significant challenge, due to the low survival rate of grafts after corneal transplantation. : A 47-year-old female presented to our hospital with persistent dryness, foreign body sensation, and blurred vision in her left eye. Diagnosis of graft-versus-host disease with corneal descemetocele in the left eye was made after detailed history review and thorough examination. Multi-layer amniotic membrane transplantation was performed in the affected eye, resulting in amelioration of the patient's symptoms. This amelioration of symptoms provided the patient with a level of comfort that permitted additional time while awaiting corneal transplantation. : We report a successful case of multi-layer amniotic membrane transplantation for the management of corneal descemetocele following allo-HSCT.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607979 | PMC |
| http://dx.doi.org/10.3390/medicina59101733 | DOI Listing |
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