AI Article Synopsis
- Vascular calcification, especially Intra Cranial Arterial Calcifications (ICAC), is common in maintenance hemodialysis (MHD) patients and is a key factor in the risk of cardiovascular disease.
- A study analyzed 280 patients, finding MHD patients had higher ICAC scores (2.3) compared to a control group (1.4), with over 90% of MHD patients experiencing some level of calcification.
- The presence of ICAC was linked to lower albumin levels and higher phosphorus and CRP levels, indicating it can predict increased mortality risk in MHD patients due to the complex interactions of inflammation and blood vessel changes.
Article Abstract
: Vascular calcification is an integral part of atherosclerosis and has been reported to be an independent risk factor for cardiovascular diSsease. Intra Cranial Arterial Calcifications (ICAC) in maintenance hemodialysis (MHD) is highly prevalent. : The aim of this retrospective study was to assess the predictors and outcomes of ICAC in MHD patients compared to a control group without kidney disease. A blinded neuroradiologist graded ICAC in brain imaging (computerized tomography) of MHD patients. Age- and sex-matched patients with normal kidney function served as the control group. : A total of 280 patients were included in the cohort; 140 of them were MHD patients with a mean ICAC score of 2.3 ± 0.2 versus a mean ICAC score of 1.4 ± 0.2 in the control group ( < 0.01). More than 90% of hemodialysis patients in our study had some degree of ICAC. Lower albumin and higher phosphorus and CRP levels were associated with increased ICACs. The multivariate analysis model for predictors of 1-year mortality demonstrated an increased odds ratio for mortality as the ICAC score increased. ICAC is very prevalent among MHD patients and results not simply from passive deposition of calcium and phosphate but rather from complex and active processes involving inflammation and structural changes in blood vessels. ICAC independently predicted all-cause mortality and may help with risk stratification of this high-risk population.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608215 | PMC |
| http://dx.doi.org/10.3390/medicina59101706 | DOI Listing |
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