AI Article Synopsis
- RH1 incompatibility can lead to hemolytic disease in newborns, prompting Switzerland to recommend fetal genotyping from maternal blood starting at 18 weeks gestation since 2020.
- This method allows for the targeted administration of RH immunoglobulin (RHIG) specifically to RH1 negative women expecting RH1 positive fetuses.
- Data from 30 months of noninvasive fetal screening showed valid results from 7072 samples, helping to avoid unnecessary RHIG treatments for over one-third of RH1 negative pregnant women, thus enhancing safety and conserving medical resources.
Article Abstract
RH1 incompatibility between mother and fetus can cause hemolytic disease of the fetus and newborn. In Switzerland, fetal genotyping from maternal blood has been recommended from gestational age 18 onwards since the year 2020. This facilitates tailored administration of RH immunoglobulin (RHIG) only to RH1 negative women carrying a RH1 positive fetus. Data from 30 months of noninvasive fetal screening is presented. Cell-free DNA was extracted from 7192 plasma samples using a commercial kit, followed by an in-house qPCR to detect exons 5 and 7, in addition to an amplification control. Valid results were obtained from 7072 samples, with 4515 (64%) fetuses typed positive and 2556 (36%) fetuses being negative. A total of 120 samples led to inconclusive results due to the presence of maternal or fetal variants (46%), followed by women being serologically RH1 positive (37%), and technical issues (17%). One sample was typed false positive, possibly due to contamination. No false negative results were observed. We show that unnecessary administration of RHIG can be avoided for more than one third of RH1 negative pregnant women in Switzerland. This reduces the risks of exposure to a blood-derived product and conserves this limited resource to women in actual need.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604374 | PMC |
| http://dx.doi.org/10.3390/biomedicines11102646 | DOI Listing |
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