Background: Transphyseal humeral separations (TPHS) are rare injuries often associated with non-accidental trauma, necessitating accurate diagnosis. This study aims to assess the accuracy of diagnosis of TPHS.
Methods: A retrospective review was conducted at five academic pediatric institutions to identify all surgically treated TPHS in patients up to 4 years of age over a 25-year period. Demographics, misdiagnosis rates, and reported misdiagnoses were noted. Comparative analyses were performed to analyze the effects of patient age and injury mechanism on misdiagnosis rates.
Results: Seventy-nine patients (average age: 17.4 months) were identified, with injury mechanisms including accidental trauma ( = 49), non-accidental trauma ( = 21), Cesarean-section ( = 6), and vaginal delivery ( = 3). Neither age nor injury mechanism were significantly associated with diagnostic accuracy in the emergency department (ED)/consulting physician group. ED/consulting physicians achieved an accurate diagnosis 46.7% of the time, while radiologists achieved an accurate diagnosis 26.7% of the time. Diagnostic accuracy did not correlate with Child Protective Services (CPS) involvement or with a delay in surgery of more than 24 h. However, a significant correlation ( = 0.03) was observed between injury mechanism and misdiagnosis rates.
Conclusion: This multicenter analysis is the largest study assessing TPHS misdiagnosis rates, highlighting the need for raising awareness and considering advanced imaging or orthopedic consultation for accurate diagnosis. This also reminds orthopedic surgeons to always have vigilant assessment in treating pediatric elbow injuries.
Level Of Evidence: Level III-Retrospective Cohort Study.
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http://dx.doi.org/10.3390/children10101716 | DOI Listing |
Small
January 2025
Department of Surgical Oncology and General Surgery Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, Ministry of Education The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
Current in vitro models for gastric cancer research, such as 2D cell cultures and organoid systems, often fail to replicate the complex extracellular matrix (ECM) found in vivo. For the first time, this study utilizes a gelatin methacryloyl (GelMA) hydrogel, a biomimetic ECM-like material, in 3D bioprinting to construct a physiologically relevant gastric cancer model. GelMA's tunable mechanical properties allow for the precise manipulation of cellular behavior within physiological ranges.
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Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Long Island Jewish Medical Center, Zucker School of Medicine at Hofstra/Northwell, Northwell Health, New Hyde Park, NY 11040, United States.
Introduction: Adenoid basal cell carcinoma is a rare cervical malignancy which is indolent in nature but resembles more commonly occurring aggressive malignancies.
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Respir Med Case Rep
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Department of Pulmonology & Respiratory Medicine, Faculty of Medicine, Universitas Sumatera Utara, Prof. dr. Chairuddin P. Lubis Universitas Sumatera Utara Hospital, Jl. Dr. Mansur No. 5, Medan, 20155, Indonesia.
Mediastinal tuberculosis poses significant diagnostic challenges due to its nonspecific clinical and radiological features, particularly in high TB incidence regions like Indonesia. Here, we present the case of A 17-year-old male, initially diagnosed with a mediastinal tumor, was later confirmed to have mediastinal tuberculosis (TB). Despite normal lab results, imaging revealed a right parahilar mass.
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June 2025
Department of Computer Science and Engineering, Vel Tech Rangarajan Dr.Sagunthala R&D Institute of Science and Technology, Tamil Nadu 600062, India.
The disease affects the optic nerve and represents the principle reasons of irreversible vision loss, mostly asymptomatic and uncontrolled. Consequently, early and accurate diagnosis is critical to prevent or reduce its effect, however, conventional diagnostic techniques often fail to provide concrete results. In this regard, we present a new approach built on Generative Adversarial Networks (GAN) and MobileNetV2 pretrained architecture for diagnosing glaucoma.
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Department of Radiological Nuclear and Laboratory Medicine - Pisa University Hospital, Via Paradisa 2, Pisa 56124, Italy.
Since rare pancreatic cystic tumors may differ from common pancreatic cystic neoplasms in terms of treatment plan and prognosis, the differential diagnosis of these diseases is clinically relevant. Various imaging tests play an important role in the differential diagnosis of rare cystic pancreatic tumors, but accurately distinguishing these diseases solely on the basis of imaging findings is challenging. The purpose of this pictorial review is to present CT and in particular MR imaging features of rare pancreatic cystic tumors and discuss potential elements for differential diagnosis.
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