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http://dx.doi.org/10.1111/nph.19344 | DOI Listing |
mBio
October 2024
Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA.
Unlabelled: Rubella virus (RuV) is an enveloped virus that usually causes mild disease in children, but can produce miscarriage or severe congenital birth defects. While in nature RuV only infects humans, the discovery of the related Ruhugu (RuhV) and Rustrela (RusV) viruses highlights the spillover potential of mammalian rubiviruses to humans. RuV buds into the Golgi, but its assembly and exit are not well understood.
View Article and Find Full Text PDFFront Immunol
June 2024
Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Munich, Roche Diagnostics GmbH, Penzberg, Germany.
PLoS One
April 2024
Department King Faisal Specialized Hospital and Research Center, Cell Therapy & Immunobiology, Riyadh, Saudi Arabia.
Epidermal growth factor receptor EGFR inhibitors are widely used as first line therapy for the treatment of non-small-cell lung cancer (NSCLC) in patients harboring EGFR mutation. However, the acquisition of a second-site mutation (T790 M) limited the efficacy and developed resistance. Therefore, discovery and development of specific drug target for this mutation is of urgent needs.
View Article and Find Full Text PDFPharmaceuticals (Basel)
March 2024
College of Pharmacy, Shaanxi University of Chinese Medicine, Shiji Ave., Xi'an-Xianyang New Ecomic Zone, Xianyang712046, China.
Mutant isocitrate dehydrogenase 1 (mIDH1) is a common driving factor in acute myeloid leukemia (AML), with the R132 mutation accounting for a high proportion. The U.S.
View Article and Find Full Text PDFNew Phytol
January 2024
Department of Biology, University of Oxford, Oxford, OX1 3RB, UK.
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