Injury risk assessment based on cadaver data is essential for informing safety standards. The common 'matched-pair' method matches energy-based inputs to translate human response to anthropometric test devices (ATDs). However, this method can result in less conservative human injury risk curves due to intrinsic differences between human and ATDs. Generally, dummies are stiffer than cadavers, so force and displacement cannot be matched simultaneously. Differences in fracture tolerance further influence the dummy risk curve to be less conservative under matched-pair. For example, translating a human lumbar injury risk curve to a dummy of equivalent stiffness using matched-pair resulted in a dummy injury risk over 80% greater than the cadaver at 50% fracture risk. This inevitable increase arises because the dummy continues loading without fracture to attenuate energy beyond the 'matched' cadaver input selected. Human injury response should be translated using an iso-energy approach, as strain energy is well associated with failure in biological tissues. Until cadaver failure, dummy force is related to cadaver force at iso-energy. Beyond cadaver failure, dummy force is related to cadaver force through failure energy. This method does not require perfect cadaver/dummy biofidelity and ensures that energy beyond cadaver failure does not influence the injury risk function.
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http://dx.doi.org/10.1007/s10439-023-03388-7 | DOI Listing |
Ann Neurol
January 2025
Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA.
Objective: Approximately 20% of familial cases of amyotrophic lateral sclerosis (ALS) are caused by mutations in the gene encoding superoxide dismutase 1 (SOD1). Epidemiological data have identified traumatic brain injury (TBI) as an exogenous risk factor for ALS; however, the mechanisms by which TBI may worsen SOD1 ALS remain largely undefined.
Methods: We sought to determine whether repetitive TBI (rTBI) accelerates disease onset and progression in the transgenic SOD1 mouse ALS model, and whether loss of the primary regulator of axonal degeneration sterile alpha and TIR motif containing 1 (Sarm1) mitigates the histological and behavioral pathophysiology.
Scand J Med Sci Sports
January 2025
Faculty of Medicine, Health, and Human Sciences, Macquarie University, Sydney, New South Wales, Australia.
Measuring lower extremity impact acceleration is a common strategy to identify runners with increased injury risk. However, existing axial peak tibial acceleration (PTA) thresholds for determining high-impact runners typically rely on small samples or fixed running speeds. This study aimed to describe the distribution of axial PTA among runners at their preferred running speed, determine an appropriate adjustment for investigating impact magnitude at different speeds, and compare biomechanics between runners classified by impact magnitude.
View Article and Find Full Text PDFPhys Ther
January 2025
SOMT University of Physiotherapy, Amersfoort, Utrecht, The Netherlands.
Objective: This systematic review aimed to determine the methodological quality of international clinical practice guidelines and the clinical credibility and implementability of recommendations regarding manipulation or mobilization treatment recommendations proposed in clinical practice guidelines for the management of people with neck pain. A secondary aim of this review was to provide an overview of recommendations for manipulation or mobilization in patients with neck pain. Manipulation or mobilization treatment of patients with neck pain is under debate for its potential risk of serious adverse events.
View Article and Find Full Text PDFEClinicalMedicine
January 2025
Medical Laboratory CSD, Kyiv 02000, Ukraine.
Background: Although the number of studies reporting war-induced effects on the health of the Ukrainian population has been growing, there are still little data on assessing patients with type 2 diabetes (T2D) during the war. This study aimed to evaluate the impact of war on T2D patients' health to define key risk factors promoting disease progression.
Methods: A survey covering various aspects of T2D patients' experience and glycemic control data was conducted from June 2022 to February 2024.
Cureus
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Critical Care Medicine, Star Care Multispeciality Hospital, Kozhikode, IND.
Background: Fluid management is a crucial critical care component, influencing outcomes such as organ function, renal integrity, and survival in critically ill patients. Recent evidence suggests that balanced crystalloids may offer advantages over isotonic saline, particularly in reducing the risk of acute kidney injury (AKI) and other complications. This study aimed to evaluate the impact of balanced crystalloids versus isotonic saline on clinical outcomes in the intensive care unit (ICU), focusing on AKI, renal replacement therapy (RRT), and mortality.
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