AI Article Synopsis
- - Lowe syndrome (LS) is a rare genetic disorder that affects various body systems, including the kidneys, eyes, and nervous system, and is observed in about 1 in 500,000 individuals, predominantly males.
- - A 25-year-old Mexican male with LS underwent diagnosis due to multiple radiolucent lesions detected in his jaw, which were confirmed as odontogenic keratocysts (OKC) after biopsy and analysis.
- - This case represents the first documented occurrence of multiple OKCs in a patient with LS, highlighting a need for more research on associated oral conditions, as well as a follow-up indicating positive bone healing after treatment.
Article Abstract
Lowe syndrome (LS) is a rare disease (1:500,000) with X-linked recessive inheritance involving the kidneys, eyes, and nervous system. A Mexican 25-year-old male patient presented for diagnosis of multiple radiolucent lesions observed on routine radiographic examination. General aspects revealed cognitive delay, eye alterations, and kidney involvement, which support the diagnosis of LS. Radiolucent well-delimited lesions were observed in both mandibular angle and symphysis. Under general anesthesia, incisional biopsy and decompression were performed. Histological aspects led to diagnosing odontogenic keratocyst (OKC) for all lesions. The lesions in the right and left mandibular angles were decompressed, and the symphyseal lesion was enucleated. A 2-month follow-up shows the bone healing process. There are few reports detailing oral findings in LS. Here, we reported the first case of multiple OKC in a patient with LS. In addition, we performed a literature review on odontogenic lesions in patients affected by LS.
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| http://dx.doi.org/10.1016/j.oooo.2023.07.008 | DOI Listing |
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