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Statin Consumption and Appealing Colors: Exploring Statin-Related Injuries for Children Under the Age of Three Years.
Cureus
November 2024
Department of Biomedical Sciences, Discipline of Pharmacology, Edward Via College of Osteopathic Medicine, Monroe, USA.
Introduction: Statins are frequently prescribed to lower the risk of atherosclerosis and cardiovascular-related diseases. While statins are considered safe, there are occasional accidental overdoses in children that warrant concern for how to protect children from unintended consumption. We aimed to determine which statins were more prone to injury, characterize the injury types commonly seen for each statin, assess the age at which statin-related injuries were most frequent, and compare statin-related injuries among genders.
View Article and Find Full Text PDFThe HEARTRISK6 Scale: Predicting Short-Term Serious Outcomes in Emergency Department Acute Heart Failure Patients.
JACC Adv
July 2024
Ottawa Hospital Research Institute, School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.
Background: Acute heart failure (AHF) is a common emergency department (ED) presentation that may have poor outcomes but often does not require hospital admission. There is little evidence to guide dispositional decisions.
Objectives: The authors sought to create a risk score for predicting short-term serious outcomes (SSO) in patients with AHF.
Validity conditions of approximations for a target-mediated drug disposition model: A novel first-order approximation and its comparison to other approximations.
PLoS Comput Biol
April 2024
Biomedical Mathematics Group, Pioneer Research Center for Mathematical and Computational Sciences, Institute for Basic Science, Daejeon, Republic of Korea.
Article Synopsis
- Target-mediated drug disposition (TMDD) describes how a drug's strong binding to a target molecule impacts its behavior in the body, affecting how it's processed (pharmacokinetics).
- Complex TMDD models can be challenging to use without specific data, leading to the development of simplified models that use quasi-steady state approximations (QSSAs), which need further validation for accuracy.
- The study validates three simplified TMDD models—mTMDD, qTMDD, and pTMDD—finding that each has specific conditions for effective use, ultimately aiding in drug development and personalized treatment strategies.
High Risk of Readmission After THA Regardless of Functional Status in Patients Discharged to Skilled Nursing Facility.
Clin Orthop Relat Res
July 2024
Department of Physical Medicine and Rehabilitation, Cleveland Clinic Foundation, Cleveland, OH, USA.
Background: The postoperative period and subsequent discharge planning are critical in our continued efforts to decrease the risk of complications after THA. Patients discharged to skilled nursing facilities (SNFs) have consistently exhibited higher readmission rates compared with those discharged to home healthcare. This elevated risk has been attributed to several factors but whether readmission is associated with patient functional status is not known.
View Article and Find Full Text PDFIs Mindfulness Associated With Safer Cannabis Use? A Latent Profile Analysis of Dispositional Mindfulness Among College Students Who Use Cannabis.
Mindfulness (N Y)
April 2023
Department of Psychology, University of New Mexico, 87131 Albuquerque, NM, Mexico.
Objectives: Previous research cites mindfulness as a protective factor against risky substance use, but the specific association between dispositional mindfulness (DM) and cannabis use has been inconsistent. Despite known heterogeneity of DM facets across college students, much of the prior research in this area has relied on variable-centered approaches. Only a handful of prior studies within the cannabis literature have utilized person-centered approaches, and only one has specifically examined unique profiles of dispositional mindfulness in relation to patterns of use among college students.
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