AI Article Synopsis
- Cytotoxic T lymphocytes target and eliminate cancer cells by recognizing specific antigens displayed with MHC class I molecules.
- A recent study by Mangalhara et al. discusses how changes in mitochondrial electron flow can enhance factors related to antigen presentation.
- This enhancement occurs through a succinate-dependent epigenetic mechanism, which suggests a link between metabolism and immune response in cancer.
Article Abstract
Cytotoxic T lymphocytes recognize and kill cancer cells when the latter present antigenic epitopes complexed with MHC class I molecules on their surface. In a recent Science paper, Mangalhara et al. show that alterations of the mitochondrial electron flow upregulate multiple factors involved in antigen presentation via a succinate-dependent epigenetic mechanism.
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| http://dx.doi.org/10.1016/j.ccell.2023.10.001 | DOI Listing |
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