Face editing represents a popular research topic within the computer vision and image processing communities. While significant progress has been made recently in this area, existing solutions: (i) are still largely focused on low-resolution images, (ii) often generate editing results with visual artefacts, or (iii) lack fine-grained control over the editing procedure and alter multiple (entangled) attributes simultaneously, when trying to generate the desired facial semantics. In this paper, we aim to address these issues through a novel editing approach, called MaskFaceGAN that focuses on local attribute editing. The proposed approach is based on an optimization procedure that directly optimizes the latent code of a pre-trained (state-of-the-art) Generative Adversarial Network (i.e., StyleGAN2) with respect to several constraints that ensure: (i) preservation of relevant image content, (ii) generation of the targeted facial attributes, and (iii) spatially-selective treatment of local image regions. The constraints are enforced with the help of an (differentiable) attribute classifier and face parser that provide the necessary reference information for the optimization procedure. MaskFaceGAN is evaluated in extensive experiments on the FRGC, SiblingsDB-HQf, and XM2VTS datasets and in comparison with several state-of-the-art techniques from the literature. Our experimental results show that the proposed approach is able to edit face images with respect to several local facial attributes with unprecedented image quality and at high-resolutions ( 1024×1024 ), while exhibiting considerably less problems with attribute entanglement than competing solutions. The source code is publicly available from: https://github.com/MartinPernus/MaskFaceGAN.
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http://dx.doi.org/10.1109/TIP.2023.3326675 | DOI Listing |
Pathogens
December 2024
Unidad de Investigación Biomédica de Zacatecas, Instituto Mexicano del Seguro Social, Zacatecas 98000, Mexico.
The development of antivirals for respiratory viruses has advanced markedly in response to the growing threat of pathogens such as Influenzavirus (IAV), respiratory syncytial virus (RSV), and SARS-CoV-2. This article reviews the advances and challenges in this field, highlighting therapeutic strategies that target critical stages of the viral replication cycle, including inhibitors of viral entry, replication, and assembly. In addition, innovative approaches such as inhibiting host cellular proteins to reduce viral resistance and repurposing existing drugs are explored, using advanced bioinformatics tools that optimize the identification of antiviral candidates.
View Article and Find Full Text PDFACS Nano
January 2025
Beijing Key Laboratory for Bioengineering and Sensing Technology, Daxing Research Institute, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, China.
Nucleic acid therapeutics represent a highly promising treatment approach in modern medicine, treating diseases at the genetic level. However, these therapeutics face numerous challenges in practical applications, particularly regarding their stability, effectiveness, cellular uptake efficiency, and limitations in delivering them specifically to target tissues. To overcome these obstacles, researchers have developed various innovative delivery systems, including viral vectors, lipid nanoparticles, polymer nanoparticles, inorganic nanoparticles, protein carriers, exosomes, antibody oligonucleotide conjugates, and DNA nanostructure-based delivery systems.
View Article and Find Full Text PDFJ Vis Exp
January 2025
Bellagen Biotechnology Co. Ltd; School of Life Sciences, Shandong Normal University;
The conventional approaches to crop breeding, which rely predominantly on time-consuming and labor-intensive methods such as traditional hybridization and mutation breeding, face challenges in efficiently introducing targeted traits and generating diverse plant populations. Conversely, the emergence of genome editing technologies has ushered in a paradigm shift, enabling the precise and expedited manipulation of plant genomes to intentionally introduce desired characteristics. One of the most widespread editing tools is the CRISPR/Cas system, which has been used by researchers to study important biology-related problems.
View Article and Find Full Text PDFProg Mol Biol Transl Sci
January 2025
R and D, Salem Microbes Private Limited, Salem, Tamil Nadu, India. Electronic address:
In the face of advancements in health care and a shift towards healthy lifestyle, diabetes mellitus (DM) still presents as a global health challenge. This chapter explores recent advancements in the areas of genetic and molecular underpinnings of DM, addressing the revolutionary potential of CRISPR-based genome editing technologies. We delve into the multifaceted relationship between genes and molecular pathways contributing to both type1 and type 2 diabetes.
View Article and Find Full Text PDFJ Cardiovasc Transl Res
January 2025
Department of Cardiology, Affiliated Hospital of Southwest Medical University, No.1 Section 1, Xiang Lin Road, Longmatan District, Luzhou, Sichuan, 646000, China.
CRISPR-Cas9 gene editing technology, as an innovative biomedical tool, holds significant potential in the prevention and treatment of atherosclerosis. By precisely editing key genes such as PCSK9, CRISPR-Cas9 offers the possibility of long-term regulation of low-density lipoprotein cholesterol (LDL-C), which may reduce the risk of cardiovascular diseases. Early clinical studies of gene editing therapies like VERVE-101 have yielded encouraging results, highlighting both the feasibility and potential efficacy of this technology.
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