causes severe foodborne illness and is the only human pathogen in the genus . Previous surveys of AMR in focused on clinical sources and food or food processing environments, with AMR in strains from wildlife and other natural ecosystems remaining under-explored. We analyzed 185 sequenced strains from wild black bears () from the United States, including 158 and 27 . and , respectively. Tetracycline resistance was the most prevalent resistance trait. In . monocytogenes, it was encountered exclusively in serotype 4b strains with the novel Tn-like element Tn. In contrast, three distinct, novel tetracycline resistance elements (Tn, , and Tn) were identified in . Interestingly, was identical to elements in from a major foodborne outbreak in the United States in 2011. The findings suggest the importance of wildlife and non-pathogenic species as reservoir for resistance elements in .
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http://dx.doi.org/10.1128/aem.01205-23 | DOI Listing |
Alzheimers Dement
December 2024
Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Background: Despite recent FDA approvement of disease-modifying treatments that reduce Aβ, the identification of novel therapeutic strategies that could delay the Alzheimer's disease (AD) development are needed. We identified and developed novel small molecule compounds that mildly inhibit mitochondrial complex I (MCI). Chronic treatment with a tool compound CP2 in 4 mouse models of familial AD was efficacious protecting against synaptic dysfunction and memory impairment, improving brain energetics and cognitive performance, reducing levels of human pTau and Ab.
View Article and Find Full Text PDFSci Rep
January 2025
Centre of Excellence for Research in Sustainable Chemistry, Department of Chemistry, Federal University of São Carlos, São Carlos, 13565-905, SP, Brazil.
Tetracyclines (TCs) are widely employed for the prevention and treatment of diseases in animals besides being deployed to promote animal growth and weight gain. Such practices result in trace amounts of TCs occurrence in water and foodstuffs of animal origin, including eggs and milk, thus posing severe health risks to humans. To ensure the food and water safety and to avoid exposure to humans, the removal of TC residues from food and water has recently garnered a considerable attention.
View Article and Find Full Text PDFEnviron Res
December 2024
Guangxi Colleges and Universities Key Laboratory of Environmental-friendly Materials and Ecological Remediation, Guangxi Key Laboratory of Advanced Structural Materials and Carbon Neutralization, School of Materials and Environment, Guangxi Minzu University, Nanning 530006, China.
Water pollution caused by antibiotics is considered a major and growing issue. To address this challenge, high-performance copper vanadate-based biochar (CuVO/BC) nanocomposite photocatalysts were prepared to develop an efficient visible light-driven photocatalytic system for the remediation of tetracycline (TC) contaminated water. The effects of photocatalyst mass, solution pH, pollutant concentration, and common anions on the TC degradation were investigated in detail.
View Article and Find Full Text PDFJ Clin Microbiol
December 2024
Laboratory of Clinical Microbiology, KU Leuven, Department of Microbiology, Immunology and Transplantation, Leuven, Flanders, Belgium.
Determination of antimicrobial resistance (AMR) in pneumococcal isolates is important for surveillance purposes and in a clinical context. Antimicrobial susceptibility testing (AST) of pneumococci is complicated by the need for exact minimal inhibitory concentrations (MICs) of beta-lactam antibiotics. Two next-generation sequencing (NGS) analysis tools have implemented the prediction of AMR in their analysis workflow, including the prediction of MICs: Pathogenwatch (https://pathogen.
View Article and Find Full Text PDFAntimicrob Agents Chemother
December 2024
National Reference Centre for Campylobacters & Helicobacters, Bordeaux, France.
Macrolides are the first-line compounds used for the treatment of campylobacteriosis. Macrolide resistance remains low in France, with mutations in being the main associated resistance mechanism. However, two erythromycin methyltransferases have also been identified(B), which is mainly described in animal reservoirs, and (N), which is strictly described in humans.
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