Serum Cholesterol Concentration on Admission in 415 Dogs Envenomated by as a Marker of Envenomation Severity and Outcome-A Retrospective Study.

Toxins (Basel)

Department of Small Animal Internal Medicine, Koret School of Veterinary Emergency and Critical Care, The Hebrew University of Jerusalem, 229 Herzel St., P.O. Box 12, Rehovot 7610001, Israel.

Published: October 2023

() (), accounts for most envenomations in humans and dogs in Israel. In humans envenomed by , serum cholesterol concentration (sChol) is inversely correlated with envenomation severity. This study examined the utility of sChol upon admission in dogs envenomed by as an envenomation severity and outcome marker. Data upon admission, including sChol, were retrospectively collected from the medical records of dogs with proven envenomation. The study included 415 dogs. The mortality rate was 11%. The heart rate upon admission was higher in non-survivors than in survivors. Signs of bleeding or hematoma and circulatory shock signs were more frequent among non-survivors compared to survivors. sChol, the platelet count, and serum albumin concentration (sAlb) were lower, while serum creatinine concentration was higher among non-survivors. sChol and sAlb were moderately, positively, and significantly correlated. sChol was significantly, negatively, albeit weakly, correlated with the length of hospitalization and the heart rate. sChol was lower in dogs admitted >12 h post-envenomation than in those admitted later. In dogs, sChol upon admission is a potential marker of severity and outcome of envenomation. The platelet count, sAlb, and sCreat might also be potential markers.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611264PMC
http://dx.doi.org/10.3390/toxins15100609DOI Listing

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