Five new eudensamane-type sesquiterpene lactones, clasamanes A-E (-), three new dolabellane-type diterpenes, clabellanes A-C (-), and fifteen known compounds (-) were isolated from the ethanolic extract of Taiwanese soft coral spp. The structures of all undescribed components (-) were determined by analysis of IR, mass, NMR, and UV spectroscopic data. The absolute configuration of new compounds was determined by using circular dichroism and DP4+ calculations. The cytotoxic activities of all isolated marine natural products were evaluated. Compound showed a significant cytotoxic effect against oral cancer cell line (Ca9-22) with an IC value of 7.26 ± 0.17 μg/mL.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608145 | PMC |
| http://dx.doi.org/10.3390/md21100529 | DOI Listing |
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