Gait speed is a simple, effective indicator of age-related disease and disability. We sought to examine the prevalence and trends of slow gait speed in older Americans. Our unweighted analytic sample included 12,427 adults aged ≥ 65 years from the 2006-2016 waves of the Health and Retirement Study. Gait speed was measured in participant residences. Persons with gait speed < 0.8 or <0.6 m/s were slow. Sample weights were used to generate nationally representative estimates. The overall estimated prevalence of slow gait speed with the <0.8 m/s cut-point was 48.6% (95% confidence interval (CI): 47.4-49.8) in the 2006-2008 waves yet was 45.7% (CI: 44.3-47.1) in the 2014-2016 waves, but this downward trend was not statistically significant ( = 0.06). The estimated prevalence of slowness with the <0.6 m/s cut-point was 21.3% (CI: 20.4-22.3) for the 2006-2008 waves, 18.5% (CI: 17.5-19.4) for the 2010-2012 waves, and 19.2% (CI: 18.2-20.2) for the 2014-2016 waves, but there were again no significant trends ( = 0.61). Our findings showed that the estimated prevalence of slow gait speed in older Americans is pronounced, and different cut-points largely inform how slowness is categorized. Continued surveillance of slowness over time will help guide screening for disablement and identify sub-populations at greatest risk for targeted interventions.
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http://dx.doi.org/10.3390/geriatrics8050095 | DOI Listing |
PLoS One
January 2025
Department of Orthopedics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Ratchathewi, Bangkok, Thailand.
Among control methods for robotic exoskeletons, biologically inspired control based on central pattern generators (CPGs) offer a promising approach to generate natural and robust walking patterns. Compared to other approaches, like model-based and machine learning-based control, the biologically inspired control provides robustness to perturbations, requires less computational power, and does not need system models or large learning datasets. While it has shown effectiveness, a comprehensive evaluation of its user experience is lacking.
View Article and Find Full Text PDFSports Med Open
January 2025
Department of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL, USA.
Background: Little is known about the lower extremity muscle co-contraction patterns during sprinting and its relation to running velocity (i.e., performance).
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD, USA.
Background: The mitochondrial cascade hypothesis suggests that mitochondrial dysfunction plays an important role in the pathogenesis of Alzheimer's disease dementia. Recent data have shown that mitochondrial DNA copy number (mtDNAcn) in human blood is associated with dementia risk and cognitive function, but which specific cognitive measures or domains are associated with mitochondrial dysfunction and whether this relationship is affected by health deterioration such as physical frailty or mitochondrial somatic mutations is not clear.
Methods: We measured mtDNAcn and heteroplasmies using fastMitoCalc and MitoCaller, respectively, from UK Biobank Whole Genome Sequencing (WGS) data at study entry (2006-2010).
Alzheimers Dement
December 2024
Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia.
Background: Dual decline in gait and cognition is associated with an increased risk of dementia, with combined gait and memory decline exhibiting the strongest association. However, little is known about the underlying brain correlates. Therefore, we aimed to examine the associations between measures of brain structure and dual decline in gait and cognition across several cognitive domains.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Background: Individuals with dual decline in gait and cognition have a greater risk of developing dementia. Understanding when gait speed declines relative to measures affected early in Alzheimer's disease can improve risk assessment.
Method: Using data for 761 participants (1,108 cognitively unimpaired visits) from the Baltimore Longitudinal Study of Aging, we estimated the trajectories of gait speed, memory (California Verbal Learning Test [CVLT] immediate recall score), hippocampal volume, and plasma Aβ/Aβ, glial fibrillary acidic protein (GFAP), and p-tau181.
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