: Little is known about gut microbiota (GM) and cardiomyopathy. Their causal relationship was explored using two-sample Mendelian randomization (TSMR) performed by R software. : The single nucleotide polymorphisms (SNPs) were further screened based on the genome-wide association studies (GWAS) of gut microbiota and cardiomyopathy obtained from an open database. TSMR was performed using an MR-Egger regression, simple estimator based on mode, weighted median method, inverse variance weighted (IVW), weighted estimator and CML-MA-BIC to explore the causal association. And the sensitivity analysis was carried out using an MR-Egger regression and the leave-one-out sensitivity test. : As for 211 GM taxa, IVW results confirmed that the class Actinobacteria ( = 0.81, = 0.021) and genus Coprobacter ( = 0.85, = 0.033) were protective factors for cardiomyopathy. The phylum Firmicutes ( = 0.87, < 0.01), family Acidaminococcaceae ( = 0.89, < 0.01), genus Desulfovibrio ( = 0.92, = 0.030) and genus Prevotella9 ( = 0.93, = 0.029) were protective factors for ischemic cardiomyopathy. The family Rhodospirillaceae ( = 1.06, = 0.036) and genus Turicibacter ( = 1.09, = 0.019) were risk factors for ischemic cardiomyopathy. The genus Olsenella ( = 0.91, = 0.032) was a protective factor for non-ischemic cardiomyopathy. The order Rhodospirillales ( = 1.14, = 0.024), family Rikenellaceae ( = 1.21, = 0.012) and genus Gordonibacter ( = 1.12, = 0.019) were risk factors for non-ischemic cardiomyopathy. The robustness of MR results was reflected in the heterogeneity ( > 0.05) and pleiotropy ( > 0.05) analyses. : A potential causal relationship of cardiomyopathy with some GM taxa has been confirmed in the current study.
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http://dx.doi.org/10.3390/jcdd10100420 | DOI Listing |
Diagnostics (Basel)
January 2025
Department of Electrocardiology, Institute of Cardiology, Faculty of Medicine, Jagiellonian University Medical College, 31-008 Kraków, Poland.
Cardiac magnetic resonance (CMR) allows for analysis of cardiac function and myocardial tissue characterization. Increased left ventricular mass (LVM) is an independent predictor of cardiovascular events; however, the diagnosis of left ventricular hypertrophy and its prognostic value strongly depend on the LVM indexation method. Evaluation of the quantity and distribution of late gadolinium enhancement assists in clinical decisions on diagnosis, cardiovascular assessment, and interventions, including the placement of cardiac implantable electronic devices and the choice of an optimal procedural approach.
View Article and Find Full Text PDFInt J Cardiol
January 2025
Department of Public Health, Universidade Federal do Ceara, Fortaleza, Brazil.
Background: Chagas cardiomyopathy (CCM) is a significant cause of ventricular arrhythmias and sudden cardiac death (SCD). Although, implantable cardiac defibrillators (ICD) have been used for all forms of non-ischemic cardiomyopathy (NICM), studies on ICD efficacy in CCM are scarce.
Objective: The present study aims to compare the long-term outcomes, mortality rates, and the occurrence of tachycardia therapies after ICD implantation in patients with CCM and NICM.
Neth Heart J
February 2025
Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands.
The European Society of Cardiology (ESC) has updated its guidelines on cardiac pacing and cardiac resynchronisation. As the majority are class II recommendations (61%) and based on expert opinion (59%), a critical appraisal for the Dutch situation was warranted. A working group has been established, consisting of specialists in cardiology, cardiothoracic surgery, geriatrics, allied professionals in cardiac pacing, and patient organisations with support from the Knowledge Institute of the Dutch Association of Medical Specialists.
View Article and Find Full Text PDFRespir Med Case Rep
December 2024
Division of Pulmonary and Critical Care, University of Rochester, Rochester, NY, USA.
An 89-year-old male with a medical history of non-ischemic cardiomyopathy was initially admitted with acute hypoxic respiratory failure attributed to heart failure exacerbation. Aside from progressive dyspnea, a non-pruritic, non-painful rash and constitutional symptoms were reported. Initial work-up was remarkable for normocytic anemia, lymphopenia, mild hypercalcemia, and elevated inflammatory markers.
View Article and Find Full Text PDFNeth Heart J
February 2025
Department of Cardiology, University Medical Centre Utrecht, Utrecht, The Netherlands.
Introduction: Current family screening approaches in dilated cardiomyopathy (DCM) depend on the presence or absence of a familial genetic variant, in which variant pathogenicity (i.e. benign or pathogenic) classification drives screening recommendations.
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