AI Article Synopsis
- Alzheimer's disease (AD) causes progressive memory loss and is linked to the buildup of β-amyloid proteins in the brain, with loneliness and social isolation identified as major risk factors.
- Oxytocin (OXT), a hormone important for social bonding, may help in rebuilding trust and relationships, and its levels can be affected by social interactions.
- Recent studies suggest that OXT could reverse memory impairments in AD models, indicating it might be a potential therapeutic target for Alzheimer's, but further research is needed to understand its role better.
Article Abstract
Alzheimer's disease (AD)-the most common cause of dementia in the elderly-is characterized by progressive memory loss and β-amyloid protein (Aβ) accumulation in the brain. Recently, loneliness was found to be a high risk factor for AD, and social isolation has become a major cause of AD. AD. Oxytocin (OXT), the main hormone involved in social bonding, has been implicated in social interactions, notably in building trust and relationships. Moreover, social isolation or social enrichment modulates the activation of neurons related to OXT. Recently, we reported that OXT reverses learning and memory impairment in AD animal models. Based on the limited number of studies currently available, OXT might be a therapeutic target for AD. Further studies are necessary in order to better understand the role of oxytocin in AD. In this review, we described the relationships between OXT, AD, and social interaction.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604997 | PMC |
| http://dx.doi.org/10.3390/cells12202426 | DOI Listing |
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