AI Article Synopsis
- A study involving 126 healthcare workers examined the impact of trace elements copper, zinc, and selenium on immune response to the mRNA COVID-19 vaccine (BNT162b2).
- Participants with low baseline levels of both copper and zinc showed significantly lower antibody responses after vaccination compared to those without these deficiencies.
- The findings suggest that adequate copper and zinc levels are important for a strong antibody response to vaccines, and highlight the need to address combined micronutrient deficiencies.
Article Abstract
The essential trace elements copper, selenium and zinc are of relevance for immunity and immune response to vaccination. In this longitudinal study, adult healthcare workers (n = 126) received two doses of an mRNA vaccine (BNT162b2), and longitudinal serum samples were prepared. Vaccine-induced antibodies and their neutralizing activity were analyzed, and the trace elements copper, zinc, and selenium along with the copper transporter ceruloplasmin were measured. Subjects with combined deficiency of copper and zinc, i.e. both in the lowest tertiles at baseline, displayed particularly low antibody titers at three (Double Q1: 13 AU/mL vs. not double Q1: 29 AU/mL) and six (Double Q1: 200 AU/mL vs. not double Q1: 425 AU/mL) weeks after vaccination (p < 0.05). The results indicate the potential importance of an adequate trace element status of copper and zinc for raising a strong vaccine-induced SARS-CoV-2 antibody response, and highlights the importance of considering combined micronutrient insufficiencies, as single deficiencies may synergize.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10597833 | PMC |
| http://dx.doi.org/10.1016/j.heliyon.2023.e20919 | DOI Listing |
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