AI Article Synopsis
- - Malaria is a major health issue in Ethiopia, with over 4.2 million cases annually, and the role of Duffy blood group expression in relation to susceptibility to malaria remains uncertain.
- - A study analyzed over 14,000 people from both community and health facility settings in malaria-endemic areas and found that those with Duffy positive expression had significantly higher infection rates compared to Duffy negatives.
- - Results suggest that Duffy negativity does not fully protect individuals from malaria, and cases among Duffy negatives are common, highlighting the need for targeted control strategies in regions with varying Duffy expression.
Article Abstract
Background: Malaria remains a significant cause of morbidity and mortality in Ethiopia with an estimated 4.2 million annual cases and 61% of the population living in areas at risk of malaria transmission. Throughout the country and are co-endemic, and Duffy expression is highly heterogeneous. The public health significance of Duffy negativity in relation to malaria in Ethiopia, however, remains unclear.
Methods: A total of 9,580 and 4,667 subjects from community and health facilities from a malaria endemic site and an epidemic-prone site in western Ethiopia were enrolled and examined for infection and Duffy expression. Association between Duffy expression, and infections were examined for samples collected from asymptomatic community volunteers and symptomatic subjects from health centers.
Results: Among the community-based cross-sectional samples, infection rate of among the Duffy positives was 2-22 fold higher than among the Duffy negatives. Parasite positivity rate was 10-50 fold higher in Duffy positive than Duffy negatives among samples collected from the health center settings and mixed and infections were significantly more common than mono infections among Duffy negative individuals. parasitemia measured by 18sRNA parasite gene copy number was similar between Duffy positives and Duffy negatives.
Conclusions: Duffy negativity does not offer complete protection against infection by , and cases of in Duffy negatives are widespread in Ethiopia, being found in asymptomatic volunteers from communities and in febrile patients from health centers. These findings offer evidence for consideration when developing control and intervention strategies in areas of endemic and Duffy heterogeneity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602065 | PMC |
| http://dx.doi.org/10.21203/rs.3.rs-3385916/v1 | DOI Listing |
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