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The 2024 updated WHO guidelines for the prevention and management of chronic hepatitis B: main changes and potential implications for the next major liver society clinical practice guidelines.
J Hepatol
December 2024
Department of metabolism Digestion and Reproduction, Division of Digestive Diseases, St Mary's Hospital, Liver Unit, Imperial College London, UK; Medical Research Council @ the London School of Hygiene and Tropical Medicine The Gambia Unit, Fajara, The Gambia. Electronic address:
Progress towards hepatitis B virus (HBV) global elimination has been slow and most countries are far to reach the elimination targets set up by the World Health Organization (WHO). The burden of chronic hepatitis B is mainly bear by resource-limited countries where only a minority of people living with HBV are diagnosed and treated and international guidelines hardly applicable in real-life. In March 2024, the WHO released its revised guidelines for the prevention and management of chronic hepatitis B.
View Article and Find Full Text PDFLevels of evidence supporting recommendations in gastroenterology.
Clin Transl Gastroenterol
December 2024
Harvard Medical School, Boston MA.
Introduction: We aimed to analyze gastrointestinal guidelines to assess quality of evidence and strength of recommendation.
Methods: We abstracted clinical practice guidelines and guidance statements from 4 American GI societies (ACG, AGA, ASGE and AASLD) and the United States Multi-Society Task Forc.
Results: Of the 3,609 statements analyzed, only 13% were supported by high level of evidence.
Implementation of a novel framework for hepatitis C diagnosis and treatment in an academic health system.
Am J Health Syst Pharm
November 2024
Specialty Pharmacy and Infusion Services, UK HealthCare, Lexington, KY, USA.
Disclaimer: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time.
View Article and Find Full Text PDFSequential Diagnostic Approach Using FIB-4 and ELF for Predicting Advanced Fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease.
Diagnostics (Basel)
November 2024
Department of Internal Medicine, Dong-A University College of Medicine, 32 Daeshingongwonro, Seo-gu, Busan 49021, Republic of Korea.
: Multiple non-invasive tests (NITs) for identifying advanced fibrosis in patients with non-alcoholic fatty liver disease (NAFLD) are available, but, due to the limitations of single NITs, the American Association for the Study of Liver Disease (AASLD) guidelines suggest a two-step strategy, combining the Fibrosis-4 Index (FIB-4) score with the Enhanced Liver Fibrosis (ELF) test to improve diagnostic accuracy and minimize unnecessary liver biopsies. However, few real-world studies have used such a sequential approach. We here evaluated the diagnostic accuracy of the ELF test in patients with recently established metabolic dysfunction-associated steatotic liver disease (MASLD) and assessed the clinical utility of applying a two-step strategy, including the ELF test following the FIB-4 score assessment, in patients with MASLD.
View Article and Find Full Text PDFPatient centered HCC surveillance - complementary roles of ultrasound and CT/MRI.
Abdom Radiol (NY)
November 2024
University of California, San Diego, San Diego, USA.
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide and is the fastest growing cause of cancer death in the United States (U.S.) In the U.
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