Phaeohyphomycosis of the Ankle Joint: A Case Report.

J Orthop Case Rep

Department of Orthopaedics, SDM College of Medical Sciences and Hospital, Shri Dharmasthala Manjunatheshwara University, Dharwad, Karnataka, India.

Published: October 2023

Introduction: Fungal infection of the musculoskeletal system is very rare. We present a rare case of fungal infection in the ankle joint. Skeletal phaeohyphomycosis (PHM) has been reported only once before in the literature.

Case Report: A 56-year-old man presented with pain and swelling in his right ankle for 2 years. There was a diffuse swelling over the medial and lateral aspect of the ankle with restricted movements. Arthroscopic biopsy was done from the ankle and histopathological examination showed pigmented fungi with few phagocytosed fungal hyphae within multinucleated giant cells indicating PHM. The patient was treated with itraconazole. At 1-year follow-up, the patient is pain free and can do his routine activities comfortably.

Conclusion: Fungal infection is a rare condition and must be kept in mind while dealing with chronic foot and ankle swelling. Early diagnosis and treatment will give good functional results.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599372PMC
http://dx.doi.org/10.13107/jocr.2023.v13.i10.3948DOI Listing

Publication Analysis

Top Keywords

fungal infection
12
ankle joint
8
ankle
5
phaeohyphomycosis ankle
4
joint case
4
case report
4
report introduction
4
fungal
4
introduction fungal
4
infection musculoskeletal
4

Similar Publications

Plants recognize a variety of environmental molecules, thereby triggering appropriate responses to biotic or abiotic stresses. Substances containing microbes-associated molecular patterns (MAMPs) and damage-associated molecular patterns (DAMPs) are representative inducers of pathogen resistance and damage repair, thus treatment of healthy plants with such substances can pre-activate plant immunity and cell repair functions. In this study, the effects of DAMP/MAMP oligosaccharides mixture (Oligo-Mix) derived from plant cell wall (cello-oligosaccharide and xylo-oligosaccharide), and fungal cell wall (chitin-oligosaccharide) were examined in cucumber.

View Article and Find Full Text PDF

is the etiologic agent of invasive aspergillosis, a life- threatening fungal pneumonia that is initiated by the inhalation of conidia (spores) into the lung. If the conidia are not cleared, they secrete large quantities of hydrolytic enzymes and toxins as they grow, resulting in extensive damage to pulmonary tissue. Stromal fibroblasts are central responders to tissue damage in many organs, but their functional response to pulmonary injury caused by has not been explored.

View Article and Find Full Text PDF

The role of PPAR in fungal keratitis.

Front Immunol

January 2025

Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, Jilin, China.

The treatment of fungal keratitis(FK) remains challenging due to delayed fungal detection and the limited effectiveness of antifungal drugs. Fungal infection can activate both innate and adaptive immune responses in the cornea. Fungi stimulate the production of oxidative stress-related biomarkers and mediate the infiltration of neutrophils, macrophages, and T cells.

View Article and Find Full Text PDF

Use of isavuconazole in mucormycosis: a systematic review.

BMC Infect Dis

January 2025

Department of Microbiology Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka, Saliyapura Sri Lanka, 50008, Sri Lanka.

Background: Mucormycosis is an opportunistic fungal infection which is associated with poor prognosis. Only a few antifungals are available in the arsenal against mucormycosis. The global guidelines for diagnosing and managing mucormycosis recommend high doses of liposomal amphotericin B (LAmB) as the first-line treatment.

View Article and Find Full Text PDF

Background: The entomopathogenic fungus, Isaria fumosorosea, shows promise as a biological control agent in managing the diamondback moth (DBM) Plutella xylostella, a highly destructive global pest of cruciferous vegetables. To date, the miRNA-mRNA regulatory networks underlying the immune response of DBM to I. fumosorosea infection are still poorly understood.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!