Most real-world behaviors - such as odor-guided locomotion - are performed with incomplete information. Activity in olfactory receptor neuron (ORN) classes provides information about odor identity but not the location of its source. In this study, we investigate the sensorimotor transformation that relates ORN activation to locomotion changes in Drosophila by optogenetically activating different combinations of ORN classes and measuring the resulting changes in locomotion. Three features describe this sensorimotor transformation: First, locomotion depends on both the instantaneous firing frequency (f) and its change (df); the two together serve as a short-term memory that allows the fly to adapt its motor program to sensory context automatically. Second, the mapping between (f, df) and locomotor parameters such as speed or curvature is distinct for each pattern of activated ORNs. Finally, the sensorimotor mapping changes with time after odor exposure, allowing information integration over a longer timescale.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10603174 | PMC |
| http://dx.doi.org/10.1038/s41467-023-42613-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The superior colliculus directs goal-oriented forelimb movements.
Cell Rep
December 2024
Centre for Neuroscience, Indian Institute of Science, Bengaluru, Karnataka 560012, India. Electronic address:
Skilled forelimb control is essential for daily living, yet our understanding of its neural mechanisms, although extensive, remains incomplete. Here, we present evidence that the superior colliculus (SC), a major midbrain structure, is necessary for accurate forelimb reaching in mice. We found that neurons in the lateral SC are active during goal-directed reaching, and by employing chemogenetic and phase-specific optogenetic silencing of these neurons, we show that the SC causally facilitates reach accuracy.
View Article and Find Full Text PDFCell-type-specific auditory responses in the striatum are shaped by feedforward inhibition.
Cell Rep
December 2024
Department of Psychiatry and Neuroscience & Physiology, New York University Grossman School of Medicine, New York, NY 10016, USA. Electronic address:
The posterior "tail" region of the striatum receives dense innervation from sensory brain regions and is important for behaviors that require sensorimotor integration. The output neurons of the striatum, D1 and D2 striatal projection neurons (SPNs), which make up the direct and indirect pathways, are thought to play distinct functional roles, although it remains unclear if these neurons show cell-type-specific differences in their response to sensory stimuli. Here, we examine the strength of synaptic inputs onto D1 and D2 SPNs following the stimulation of upstream auditory pathways.
View Article and Find Full Text PDFApplication of a Dual Optogenetic Silencing-Activation Protocol to Map Motor Neurons Driving Rolling Escape Behavior in Larvae.
Bio Protoc
December 2024
Department of Biology, Texas A&M University, College Station, TX, USA.
larvae exhibit rolling motor behavior as an escape response to avoid predators and painful stimuli. We introduce an accessible method for applying optogenetics to study the motor circuits driving rolling behavior. For this, we simultaneously implement the Gal4-UAS and LexA-Aop binary systems to express two distinct optogenetic channels, GtACR and Chrimson, in motor neuron (MN) subsets and rolling command neurons (Goro), respectively.
View Article and Find Full Text PDFNeuronal Sequences and dynamic coding of water-sucrose categorization in rat gustatory cortices.
iScience
December 2024
Laboratory Neurobiology of Appetite, Department of Pharmacology, Center for Research and Advanced Studies of the National Polytechnic Institute, Mexico City 07360, Mexico.
The gustatory system allows us to perceive and distinguish sweetness from water. We studied this phenomenon by recording neural activity in rats' anterior insular (aIC) and orbitofrontal (OFC) cortices while they categorized varying sucrose concentrations against water. Neurons in both aIC and OFC encoded the categorical distinction between sucrose and water rather than specific sucrose concentrations.
View Article and Find Full Text PDFAberrant network topological structure of sensorimotor superficial white-matter system in major depressive disorder.
J Zhejiang Univ Sci B
December 2024
Center for Cognition and Brain Disorders / Department of Neurology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou 311121, China.
Article Synopsis
- White-matter tracts are essential for transmitting sensory and motor information and connecting different areas of the brain, but their role in major depressive disorder (MDD) is not well understood.
- This study examined the white-matter networks in 233 MDD patients compared to 257 healthy controls using advanced MRI techniques.
- The results showed significant changes in the white-matter structure related to sensorimotor functions, allowing researchers to effectively differentiate MDD patients from healthy individuals based on brain network features.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!